AIMC Journal:
bioRxiv

Showing 2421 to 2430 of 4979 articles

Generative AI Guided Design of High-Affinity T cell Receptors

bioRxiv Feb 12, 2026
Developing T cell receptors (TCRs) with sufficiently high affinity for tumor antigens (TAs) remains a fundamental challenge in TCR-T immunotherapy. Experimental methods such as affinity maturation and high-throughput screening have enabled the identi...
View on bioRxiv DOI

Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions

bioRxiv Feb 11, 2026
Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments. However, how these distinct representations emerge from the underlying local circuit architecture remains unknown. Using two-photo...
View on bioRxiv DOI

AmesNet: A Task-Conditioned Deep Learning Model with Enhanced Sensitivity and Generalization in Ames Mutagenicity Prediction

bioRxiv Feb 11, 2026
Regulatory agencies require comprehensive genotoxicity assessments for all novel small-molecule therapeutics prior to human trials. Developers often delay these studies until a candidate is nearing regulatory submission because they are expensive and...
View on bioRxiv DOI

Neural Dynamics of Automatic Speech Production

bioRxiv Feb 11, 2026
Speech is a defining human behavior, and this ability depends critically on speech motor cortex. While the ventral precentral and postcentral gyri are classically regarded as chiefly articulatory and somatosensory regions, a growing body of literatur...
View on bioRxiv DOI

VC-RDAgent: An efficient rare disease diagnosis agent via virtual case construction informed by hybrid statistical-metric and hyperbolic-semantic prioritization

bioRxiv Feb 11, 2026
While Large Language Models (LLMs) have shown promise in clinical decision support, current Retrieval-Augmented Generation (RAG) paradigms face a fundamental bottleneck in rare disease diagnosis: the scarcity, privacy restrictions, and extreme hetero...
View on bioRxiv DOI

BRIDGE: Biological Antimicrobial Resistance Inference viaDomain-Knowledge Graph Embeddings

bioRxiv Feb 11, 2026
Antimicrobial resistance (AMR) is a growing global health crisis, responsible for an estimated 1.27 million deaths in 2019 alone. traditional approaches to identifying antibiotic resistance genes (ARGs) are often labour-intensive and limited in their...
View on bioRxiv DOI

Identification and experimental verification of key genes related to the Ras signaling pathway and the Hippo signaling pathway in osteoarthritis based on transcriptome data

bioRxiv Feb 11, 2026
Background Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the progressive deterioration of articular cartilage, significantly impacting the quality of life in middle-aged and elderly populations. The Ras and Hippo signal...
View on bioRxiv DOI

A machine learning approach to identify key Epigenetic Transcripts for Ageing research in human blood (Epitage)

bioRxiv Feb 11, 2026
DNA methylation is an established biomarker of human ageing, and analysing CpGs grouped by transcript as functional units may reveal new insights into the processes of ageing. In this study, we analyzed the GSE87571 dataset (714 samples from 14-94 ye...
View on bioRxiv DOI

Network-based integration of gene expression and DNA methylation identifies prognostic biomarkers for early-stage pancreatic cancer

bioRxiv Feb 11, 2026
Pancreatic ductal adenocarcinoma remains one of the most lethal malignancies, largely due to the absence of reliable early stage biomarkers. Here, we present a network-based multi-omics framework that integrates gene expression and DNA methylation da...
View on bioRxiv DOI

A spectral framework for measuring diversity in multiple sequence alignments

bioRxiv Feb 11, 2026
Machine learning (ML) methods for proteins and RNAs rely on multiple sequence alignments (MSAs) and related datasets such as experimental mutagenesis libraries, yet the amount of usable information they contain remains unclear. Here, a spectral measu...
View on bioRxiv DOI
Popular Topics
Popular Journals