AIMC Journal:
bioRxiv

Showing 2451 to 2460 of 4979 articles

A Systematic Benchmark for Peptide Property Prediction

bioRxiv Feb 10, 2026
Accurate prediction of peptide physicochemical properties and biological activities is critical for rational peptide design and high-throughput screening. However, current research is often constrained by heterogeneous data sources and inconsistent e...
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α-Synuclein Strain Dynamics Correlate with Cognitive Shifts in Parkinson's Disease

bioRxiv Feb 9, 2026
-Synuclein (-syn) strains can serve as discriminators between Parkinson's disease (PD) and related -synucleinopathies. The relationship between -syn strain dynamics and clinical performance as patients transition from normal cognition (NC) to cogniti...
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A high-fat hypertensive diet induces a coordinated perturbation signature across cell types in thoracic perivascular adipose tissue

bioRxiv Feb 9, 2026
Perivascular adipose tissue (PVAT), an intriguing layer of fat surrounding blood vessels, regulates vascular tone and mediates vascular dysfunction through mechanisms that are not well understood. Here we show with single nucleus RNA-sequencing of th...
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Designing AI-programmable therapeutics with the EDEN family of foundation models

bioRxiv Feb 9, 2026
The ability to interpret, modify, and design DNA has driven many of the most significant advances in modern medicine, from diagnostics, biologics, and vaccines to cell and gene therapies. However, the inherent complexity of biological systems means t...
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A shape-constrained regression and wild bootstrap framework for reproducible drug synergy testing

bioRxiv Feb 9, 2026
High-throughput drug combination screens motivate computational methods to identify synergistic pairs, yet synergy is typically quantified by heuristic scores (Bliss, HSA, Loewe, ZIP) that provide no statistical inference and can be unstable or undef...
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A ML-framework for the discovery of next-generation IBD targets using a harmonized single-cell atlas of patient tissue

bioRxiv Feb 9, 2026
Target discovery for IBD has traditionally relied on genetic associations, which lack the cellular resolution needed to identify novel, actionable, cell type-specific disease pathways. Here, we describe an integrated analytical and experimental frame...
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AI-driven discovery and engineering of human endogenous nanocage proteins for mRNA delivery

bioRxiv Feb 9, 2026
Safe and effective gene delivery remains a central challenge for therapeutic applications. While non-viral and viral vectors have enabled substantial progress, their reliance on non-human components often triggers immune responses, limiting their use...
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Preserved Embedding of Neural Population Activity for Brain Computer Interfaces

bioRxiv Feb 9, 2026
Inferring stable neural representations of motor cortical dynamics is essential for brain-computer interface (BCI) control. However, neural recordings during similar behaviors exhibit intrinsic variability across recording sessions, subjects, and tas...
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SpliceRead: Improving Canonical and Non-Canonical Splice Site Prediction with Residual Blocks and Synthetic Data Augmentation

bioRxiv Feb 9, 2026
Accurate splice site prediction is fundamental to understanding gene expression and its associated disorders. However, most existing models are biased toward frequent canonical sites, limiting their ability to detect rare but biologically important n...
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TM-Vec 2: Accelerated Protein Homology Detection for Structural Similarity

bioRxiv Feb 9, 2026
Understanding protein function is an essential aspect of many biological applications. The exponential growth of protein sequence databases has created a critical bottleneck for structural homology detection. While billions of protein sequences have ...
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