AIMC Journal:
bioRxiv

Showing 2481 to 2490 of 4979 articles

Altered Baseline Brain Network Topology in High-Risk Individuals Progressing to Mild Cognitive Impairment

bioRxiv Feb 7, 2026
Background: Identifying early brain-based markers of cognitive decline is critical for preventive strategies in Alzheimer's disease. Individuals with a familial risk may exhibit subtle functional brain changes years before clinical symptoms emerge. T...
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Model-Driven Hybrid AI Framework for End-to-End Autonomous Decision-Making in Drug Development

bioRxiv Feb 6, 2026
Decision-making in drug development spans heterogeneous stages from molecular design to clinical optimization, yet computer-aided workflows across stages remain fragmented, limiting traceability from evidence-derived clinical questions to simulation ...
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Depth-Sensitive Optical Property Characterization Using Multi-Frequency Laparoscopic SFDI

bioRxiv Feb 6, 2026
Accurate knowledge of tissue absorption () and reduced scattering (s'), parameters is required to plan and monitor laparoscopic chemophototherapy (CPT) in ovarian cancer, including light dosimetry and quantitative fluorescence mapping of porphyrin ph...
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Adaptive spatio-temporal phase retrieval for ultra-short pulse wavefront shaping

bioRxiv Feb 6, 2026
Beam shaping of ultra-short pulses is essential for medical ultrasound, where single-cycle excitations are required to achieve high axial resolution and improve frame rate. Conventional methods, such as the Gerchberg Saxton (GS) algorithm or more rec...
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Unified imputation of missing data modalities and features in multi-omic data via shared representation learning

bioRxiv Feb 6, 2026
Multi-omic studies promise a more comprehensive view of biological systems by jointly measuring multiple molecular layers. In practice, however, such datasets are rarely complete: entire molecular modalities may be missing for many samples, and obser...
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BOLE: A Knowledge-Enhanced Multi-Agent Framework for Intelligent Genomic Breeding

bioRxiv Feb 6, 2026
Genomic breeding has become increasingly data-intensive, yet the practical integration of heterogeneous bioinformatics tools into coherent analytical workflows remains a major bottleneck. To address this, we present BOLE, a knowledge-enhanced multi-a...
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Mapping trans-eQTLs at single-cell resolution using Latent Interaction Variational Inference.

bioRxiv Feb 6, 2026
Single-cell expression quantitative trait loci (eQTL) studies hold promise for linking genetic variants to changes in gene expression in individual cells, thereby offering deeper insights into the genetic basis of human traits and diseases. Existing ...
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Practical utility of sequence-to-omics models for improving the reproducibility of genetic fine-mapping

bioRxiv Feb 6, 2026
Recent advances in deep learning have led to the development of sequence-to-omics (S2O) models that predict molecular phenotypes directly from DNA sequences. Here, we systematically evaluate the utility of these models, e.g., AlphaGenome, Borzoi, Enf...
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ASPECT: Alternative Splicing Event Classification with Transformers

bioRxiv Feb 6, 2026
Motivation: Alternative splicing (AS) is a fundamental regulatory mechanism that expands transcriptomic and proteomic diversity by generating multiple mRNA isoforms from a single gene. Aberrant AS has been implicated in numerous diseases through the ...
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A lightweight, ultrafast and general embedding framework for large-scale spatial omics data

bioRxiv Feb 6, 2026
Deciphering ultra-large-scale omics data with minimal resources while maintaining high computational efficiency is a longstanding challenge in biology. Here, we present Local Pooling (LP), a lightweight, ultrafast and general framework that leverage ...
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