AIMC Journal:
bioRxiv

Showing 2571 to 2580 of 4979 articles

Distance-Restraint-Guided Diffusion Models for Sampling Protein Conformational Changes and Ligand Dissociation Pathways

bioRxiv Jan 31, 2026
Protein conformational dynamics and ligand binding processes are fundamental to biological function, yet their systematic sampling and thermodynamic characterization remain challenging. Here, we present a distance-restraint-guided inference method th...
View on bioRxiv DOI

CyclicMPNN: Stable Cyclic Peptide Sequence Generation

bioRxiv Jan 31, 2026
Cyclic peptides are a promising class of therapeutics due to their attractive drug qualities such as increased structural stability, cell permeability, and resistance to proteolytic degradation. With recent advancements in cyclic peptide backbone gen...
View on bioRxiv DOI

DynaPIN: A Tool for Characterizing Dynamic Protein Interfaces

bioRxiv Jan 31, 2026
Static structural models often fail to capture the dynamic mechanisms of protein interactions. To address this, we introduce DynaPIN, an open-source pipeline for extracting dynamic interface fingerprints from molecular simulations. DynaPIN unifies qu...
View on bioRxiv DOI

Tissue-to-Analysis Framework Enables Multiscale Mapping of the Architectural and Cellular Organization in the Human Dorsal Root Ganglion

bioRxiv Jan 31, 2026
Transcriptomic studies have helped us understand the dorsal root ganglia's cellular milieu, yet our knowledge of protein expression and spatial organization/architecture remains less defined. Here we establish a comprehensive resource from processing...
View on bioRxiv DOI

Longevity Bench: Are SotA LLMs ready for aging research?

bioRxiv Jan 30, 2026
Aging is a core biological process observed in most species and tissues, which is studied with a vast array of technologies. We argue that the abilities of AI systems to emulate aging and to accurately interpret biodata in its context are the key cri...
View on bioRxiv DOI

Nab-paclitaxel fused with the de novo designed receptor binder exhibits enhanced tumor targeting and therapeutic efficacy

bioRxiv Jan 30, 2026
Chemotherapy has been widely used in cancer treatment, but most of the chemotherapeutic drugs rely mainly on passive accumulation due to lack of target specificity, which may lead to systemic toxicity and limited clinical utility. Recent advances in ...
View on bioRxiv DOI

Linear and Nonlinear Oscillatory Functional Brain Networks in Euthymic Bipolar Disorder Classification

bioRxiv Jan 30, 2026
Functional brain network (FBN) dysconnectivity has been repeatedly reported in bipolar disorder (BD). However, it remains unclear how this dysconnectivity manifests from the perspective of oscillatory FBNs, that is, which network measures and frequen...
View on bioRxiv DOI

Conserved Residues in the Gα interface show subtype specificity in Gβγ coupling

bioRxiv Jan 30, 2026
Although the structural basis of selective G-protein coupling to G protein coupled receptors (GPCRs) is well characterized, the mechanisms underlying selective interactions between distinct G subtypes (Gs, Gi, Gq, and G12/13) and G{beta}{gamma} remai...
View on bioRxiv DOI

Strategic Segmentation: A Nash Equilibrium based Approach for Weed Segmentation in Agricultural Fields

bioRxiv Jan 30, 2026
Weeds present a major challenge to agricultural productivity, competing with crops for critical resources like water, nutrients, and sunlight, resulting in significant yield reductions. Prompt weed identification is essential for enabling effective c...
View on bioRxiv DOI

Machine Learning Identifies Distinct Treg-Mediated Remodeling in HFpEF Hearts Treated with Neonatal Mesenchymal Stem Cells and Their Secretome

bioRxiv Jan 30, 2026
Background: Heart failure with preserved ejection fraction (HFpEF) remains a major therapeutic challenge due to its complex pathophysiology and pronounced heterogeneity. Regenerative approaches using neonatal mesenchymal stromal cells (nMSCs) and the...
View on bioRxiv DOI
Popular Topics
Popular Journals