AIMC Journal:
bioRxiv

Showing 251 to 260 of 4935 articles

REN-former prioritizes candidate regulators of kidney disease-state transitions through single-cell foundation modeling and human genetics

bioRxiv Sep 15, 2026
Background Acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition is associated with dynamic changes in tubular cell state. However, conventional single-cell transcriptomic analyses primarily identify genes differentially expressed betw...
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HeartVar: An LLM-Assisted Tool for Clinical Classification of Variants in Cardiovascular Disease Cohorts

bioRxiv Sep 15, 2026
Manual clinical DNA variant classification is the bottleneck of every clinical and research rare disease workflow. The process typically requires a curator to assemble evidence from numerous databases, weigh 28 criteria, reconcile competing evidence,...
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POME: Graph-based embeddings for partially observed mixed-type data

bioRxiv Sep 15, 2026
Partially observed mixed-type (POM) data, as often encountered in clinical, epidemiological, and phenotypic datasets, are very common in biomedical research. Yet, advanced data analysis and machine learning based on POM data is complicated by their h...
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Septin inhibitors exert opposing effects on distinct higher-order septin structures in melanoma cells

bioRxiv Sep 14, 2026
Septins are cytoskeletal GTPases that assemble into diverse higher-order structures with context-dependent mechanical and signaling functions. Recent work identified a septin-dependent pro-survival pathway in metastatic cancer cells, termed bleb sign...
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Threat imminence and estimates of agency dictate proactive and reactive defensive behaviors in active place avoidance

bioRxiv Sep 14, 2026
Defensive survival behaviors are shaped by both danger attributes and internal physiological states. Well-characterized defensive responses depend not only on whether danger is potential or perceived, but also on its spatial and or temporal proximity...
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Multigenerational machine learning-based genomic prediction for dermo resistance in eastern oyster Crassostrea virginica

bioRxiv Sep 14, 2026
Dermo disease caused by the protist Perkinsus marinus poses a major threat to Eastern oyster aquaculture. We previously conducted genomic selection for dermo resistance and found increased effectiveness over phenotypic selection. Here, we report impr...
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Sensory variation and behavioural degeneracy: a framework for interpreting heterogeneity in the gut-brain axis

bioRxiv Sep 14, 2026
Gut microbiome differences are frequently interpreted as reflecting underlying biological differences between individuals. When outcomes are mediated by behaviour, however, this mapping may be fundamentally non-unique. This limits causal inference in...
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Discrete synaptic states and context-modulated readouts support continual learning

bioRxiv Sep 14, 2026
Biological neural systems learn new behaviors while retaining earlier ones, whereas sequentially trained artificial networks often overwrite parameters and forget previously learned behaviors. We introduce the Context-modulated Synaptic-states Recurr...
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Heterogeneous graph neural networks with biological prior knowledge for interpretable drug repurposing in triple-negative breast cancer

bioRxiv Sep 14, 2026
Drug repurposing offers a cost-effective path to new therapies for triple-negative breast cancer (TNBC), a subtype with limited targeted treatment options. We present PRECISION, a framework integrating transcription factor (TF) regulatory networks, p...
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Multi-Methodological Characterization of Sleep Deprivation: From Standard EEG Power Spectra to Aperiodic Dynamics in Humans and Mice.

bioRxiv Sep 14, 2026
Sleep deprivation is a potent, rapid-acting therapeutic intervention for major depressive disorder, yet its underlying neural mechanisms remain poorly understood, hindering the development of predictive biomarkers. Here, we systematically characteriz...
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