AIMC Journal:
bioRxiv

Showing 2701 to 2710 of 4979 articles

ComPRePS: Unlocking Scalable AI Analysis for Computational Renal Pathology

bioRxiv Jan 20, 2026
Digital pathology using whole slide imaging (WSI) and artificial intelligence (AI) has the potential to transform diagnostic workflows, but adoption remains limited by technical complexity and scalability. We developed the Computational Renal Patholo...
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Characterizing Highly Conserved Fragments in 3'UTRs via Computational and Transfer Learning Approaches

bioRxiv Jan 20, 2026
3' untranslated regions (3' UTRs) serve as regulatory platforms that modulate translation, mRNA localization, and stability through the binding of regulators, such as RNA-binding proteins (RBPs) and miRNAs, in a sequence-specific manner. These vital ...
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Sleep dynamics and epileptogenesis following Kainic acid in epilepsy-susceptible (DBA/2J) and epilepsy-resistant (C57BL/6) mice

bioRxiv Jan 20, 2026
Susceptibility to epileptogenesis varies in humans and outbred mouse strains. We hypothesized that baseline sleep abnormalities increase susceptibility to epileptogenesis following Kainic acid (KA) and abnormal circadian rhythm or sleep homeostasis (...
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Medea: An omics AI agent for therapeutic discovery

bioRxiv Jan 20, 2026
AI agents promise to empower biomedical discovery, but realizing this promise requires the ability to complete transparent, long-horizon analyses using tools. Agents must make intermediate decisions explicit, and validate each decision and output aga...
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CellFluxV2: An Image Generative Foundation Model for Virtual Cell Modeling

bioRxiv Jan 20, 2026
Building a virtual cell that simulates cellular behavior in silico is a central goal of computational biology. We introduce CellFluxV2, an image-generative model that predicts how cell morphologies change in response to chemical and genetic perturbat...
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Spatial Decoding of Tertiary Lymphoid Structure Maturation in Non-Small Cell Lung Cancer Using Deep Neural Networks

bioRxiv Jan 20, 2026
Understanding the role of tertiary lymphoid structures (TLS) is crucial in non-small cell lung cancer (NSCLC), as they are associated with patient prognosis and treatment outcomes. Specific cellular ecosystems that originate anti-tumor activity or pr...
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Comparison of Deep Learning Approaches for Extreme Low-SNR Image Restoration

bioRxiv Jan 20, 2026
Background: Live-cell fluorescence microscopy enables the study of dynamic cellular processes. However, fluorescence microscopy can damage cells and disrupt these dynamic processes through photobleaching and phototoxicity. Reducing light exposure mit...
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Generating Structurally Diverse Therapeutic Peptides with GFlowNet

bioRxiv Jan 19, 2026
Reinforcement learning approaches for therapeutic peptide generation suffer from mode collapse, converging to narrow regions of sequence space even when explicit diversity penalties are applied. Fine-grained analysis reveals persistent mode-seeking b...
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dgiLIT: A Method for Prioritization and AI Curation of Drug-Gene Interactions

bioRxiv Jan 19, 2026
IMPORTANCE: The Drug-Gene Interaction Database (DGIdb) has a long history of driving hypothesis generation for biomedical research through the careful curation of drug-gene interaction data from primary and secondary sources with supporting literatur...
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A predicted cancer dependency map for paralog pairs

bioRxiv Jan 19, 2026
Background Genome-wide CRISPR screening has enabled the development of dependency maps in hundreds of cancer cell lines, facilitating the identification of genetic vulnerabilities associated with specific biomarkers. Paralogs, despite being common dr...
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