AIMC Journal:
bioRxiv

Showing 2721 to 2730 of 4979 articles

TomoSegNet: Augmented membrane segmentation for cryo-electron tomography by simulating the cellular context

bioRxiv Jan 16, 2026
Membrane segmentation is an essential task in the workflow for processing cryo-electron tomography data. Recently, machine learning algorithms have successfully been adopted to perform membrane segmentation. However, the performance of these approach...
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TcrDesign: De novo design of epitope specific full-length T cell receptors

bioRxiv Jan 16, 2026
T cell receptors (TCRs) are essential for adaptive immune recognition. Recently computational tools have been developed to predict the interactions between TCR and epitope, and artificial intelligence models have been proposed to generate the complem...
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PathDiffusion: modeling protein folding pathway using evolution-guided diffusion

bioRxiv Jan 16, 2026
Despite remarkable advances in protein structure prediction, a fundamental question remains unresolved: how do proteins fold from unfolded conformations into their native states? Here, we introduce PathDiffusion, a novel generative framework that sim...
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GARD: Genomic Data based Drug Repurposing in Head and Neck Cancer with Large Language Model Validation

bioRxiv Jan 16, 2026
Background/ObjectivesHead and neck cancer (HNC) represents the seventh most common cancer diagnosis globally, yet current treatments, including surgery, radiation, and immunotherapy, have shown limited improvement in outcomes. Drug repurposing offers...
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Transmission Dynamics of Eastern Equine Encephalitis Infection Rates: The Role of Avian Host Stage and Differential Mosquito Exposure

bioRxiv Jan 16, 2026
Eastern equine encephalitis virus (EEEV) is a deadly arboviral pathogen with 30% severe case fatality. EEEV exhibits pronounced 2-3 year cyclical outbreak patterns in the northeastern United States, linked to shifts in mosquito feeding preferences be...
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HERMES: Holographic Equivariant neuRal network model for Mutational Effect and Stability prediction

bioRxiv Jan 15, 2026
Accurately predicting how amino acid substitutions alter protein function is a central challenge in biology, with applications from interpreting disease variants to engineering vaccines and therapeutic proteins. We introduce HERMES, a family of fast,...
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A genotype-phenotype transformer to assess and explain polygenic risk

bioRxiv Jan 15, 2026
Genome-wide association studies have linked millions of genetic variants to biomedical phenotypes, but their utility has been limited by lack of mechanistic understanding and widespread epistatic interactions. Recently, Transformer models have emerge...
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Histological aging signatures enable tissue-specific disease prediction from blood

bioRxiv Jan 15, 2026
Aging, the leading risk factor for numerous diseases, manifests through diverse structural and architectural changes in human tissues, providing an opportunity to quantify and interpret tissue-specific aging. To address this, we present a comprehensi...
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NeuroSimo: an open-source software for closed-loop EEG- or EMG-guided TMS

bioRxiv Jan 15, 2026
ObjectiveOur goal was to create open-source software for closed-loop EEG-TMS that allows researchers to rapidly prototype and develop novel stimulation paradigms in a high-level programming language. This addresses the limitations of current solution...
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OpenDVP: An experimental and computational framework for community-empowered deep visual proteomics

bioRxiv Jan 15, 2026
Deep visual proteomics (DVP) is an emerging approach for cell type-specific and spatially resolved proteomics. However, its broad adoption has been constrained by the lack of an open-source end-to-end workflow in a community-driven ecosystem. Here, w...
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