AIMC Journal:
bioRxiv

Showing 2771 to 2780 of 4979 articles

Neural Maturation Stabilizes Representations and Supports Understanding of Complex Concepts

bioRxiv Jan 1, 2025
Remarkable advances in AI do not necessarily rely on modern molecular biology. Here, I highlight the importance of neural maturation in neural network information processing. In both supervised and reinforcement learning, immature synaptic transmissi...
View on bioRxiv DOI

Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold

bioRxiv Jan 1, 2025
Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their e...
View on bioRxiv DOI

Interplay between high-energy quenching and state transitions in Chlamydomonas reinhardtii: a single-cell approach

bioRxiv Jan 1, 2025
Studying cell-to-cell heterogeneity is essential to understand how unicellular organisms respond to stresses. We introduce a single-cell analysis framework that enables the study of intercellular heterogeneity of photosynthetic traits, particularly t...
View on bioRxiv DOI

Automated Registration and Clustering for Enhanced Localization Atomic Force Microscopy of Flexible Membrane Proteins

bioRxiv Jan 1, 2025
Atomic Force Microscopy (AFM) can create images of biomolecules under near-native conditions but suffers from limited lateral resolution due to the finite AFM tip size and recording frequency. The recently developed Localization Atomic Force Microsco...
View on bioRxiv DOI

Oxytocin neurons signal state-dependent transitions from rest to thermogenesis and behavioral arousal in social and non-social settings

bioRxiv Jan 1, 2025
Core body temperature (Tb) is defended within narrow limits through thermoregulatory behaviors like huddling, nesting, and physical activity as well as autonomic responses like brown fat thermogenesis and peripheral vasodilation. While Tb displays re...
View on bioRxiv DOI

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

bioRxiv Jan 1, 2025
Stroke is a leading cause of disability and death due to the brain’s limited ability to regenerate damaged neural circuits. To date, stroke patients have only few therapeutic options and are often left with considerable disabilities. Induced pluripot...
View on bioRxiv DOI

OpenSpliceAI: An efficient, modular implementation of SpliceAI enabling easy retraining on non-human species

bioRxiv Jan 1, 2025
The SpliceAI deep learning system is currently one of the most accurate methods for identifying splicing signals directly from DNA sequences. However, its utility is limited by its reliance on older software frameworks and human-centric training data...
View on bioRxiv DOI

Benchmarking of signaling networks generated by large language models

bioRxiv Jan 1, 2025
Computational models of signaling networks provide frameworks for predicting how molecular cues guide cell decisions. But they are typically limited by manual curation from incomplete literature. Here, we test whether general-purpose large language m...
View on bioRxiv DOI

Long-Term Potentiation and Closed-Loop Learning in Paired Brain Organoids for CNS Drug Discovery

bioRxiv Jan 1, 2025
Learning and memory, central to cognitive function and critical targets for drug discovery in neurological disorders, fundamentally rely on electrophysiological mechanisms such as short- term potentiation (STP) and long-term potentiation (LTP). We de...
View on bioRxiv DOI

Bridging polarities in metabolomics: Cross-ionization mode chemical similarity prediction between tandem mass spectra

bioRxiv Jan 1, 2025
Mass spectrometry is a cornerstone of untargeted metabolomics, enabling the characterization of metabolites in both positive and negative ionization modes. However, comparisons across ionization modes have remained a substantial challenge due to the ...
View on bioRxiv DOI
Popular Topics
Popular Journals