AIMC Journal:
bioRxiv

Showing 2911 to 2920 of 4993 articles

Machine Learning-Driven Optimization of Specific, Compact, and Efficient Base Editors via Single-Round Diversification

bioRxiv Jan 1, 2025
Cytosine and adenosine base editors show great potential in research and clinical applications. Current iterations of the deaminase—the enzyme used to create precise single-nucleotide changes via base editing—exhibit various off-target effects, inclu...
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Simpler predictive models provide higher accuracy for ovarian cancer detection

bioRxiv Jan 1, 2025
Ovarian cancer remains a danger to women’s health, and accurate screening tests would likely increase survival. Two established protein biomarkers, CA125 and HE4, have been shown to work well in isolation, but achieve even higher accuracy when combin...
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A naturalistic reinforcement learning task uncovers historical neural representations

bioRxiv Jan 1, 2025
Exploration is essential for reinforcement learning (RL) in human development, facilitating cognitive and behavioral adaptation. However, conventional RL paradigms in neuroimaging studies often rely on highly constrained search spaces and artificial,...
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ASCENT: Annotation-free Self-supervised Contrastive Embeddings for 3D Neuron Tracking in Fluorescence Microscopy

bioRxiv Jan 1, 2025
Tracking individual neurons in dense 3D microscopy recordings of fast-moving, deforming organisms is a critical challenge in neuroscience. This task is often hindered by complex tissue motion and the need for laborious manual annotation. Here, we int...
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Region-specific mechanosensation controls Drosophila postural control behaviour

bioRxiv Jan 1, 2025
The relation between regional morphological features derived from the bilaterian body plan and the behaviours necessary to extract utility from such structures is not well understood. Here we use the Drosophila larva to investigate this ‘form-functio...
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The Use of DeepQSAR Models for The Discovery of Peptides with Enhanced Antimicrobial and Antibiofilm Potential

bioRxiv Jan 1, 2025
Increasing concerns regarding prolonged antibiotic usage have spurred the search for alternative treatments. Antimicrobial peptides (AMPs), first discovered in the 1980s, have exhibited significant potential against a broad range of bacteria [1]. Sho...
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Generalizability of machine learning models for plant traits using hyperspectral reflectance data: The case of maize

bioRxiv Jan 1, 2025
Hyperspectral reflectance provides rapid and precise phenotyping of plants in a non-destructive manner both in field and well-controlled settings. The resulting data have been used to devise machine learning (ML) models for paired measurements of dif...
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Temporal foundation model unveils ancient Hepatitis B virus evolution

bioRxiv Jan 1, 2025
Since ancient hepatitis B virus (HBV) sequencing data are scarce and incomplete, the evolutionary dynamics of HBV have long remained enigmatic. This data gap hinders a comprehensive understanding of HBV genetic variations, evolutionary trajectories, ...
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XAI-based Data Visualization in Multimodal Medical Data

bioRxiv Jan 1, 2025
Explainable Artificial Intelligence (XAI) is crucial in healthcare as it helps make intricate machine learning models understandable and clear, especially when working with diverse medical data, enhancing trust, improving diagnostic accuracy, and fac...
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Predicting Brain Volumes from Anthropometric and Demographic Features: Insights from UK Biobank Neuroimaging Data

bioRxiv Jan 1, 2025
Brain size measures are well-studied and often treated as a confound in volumetric neuroimaging analyses. Yet their relationship with body anthropometric measures and demographics remains underexplored. In this study, we examined those relationships ...
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