AIMC Journal:
bioRxiv

Showing 2921 to 2930 of 4993 articles

Novel Computational Pipeline to Identify Target Sites for Broad Spectrum Antiviral Drugs

bioRxiv Jan 1, 2025
Emerging viruses pose an ongoing threat to human health. While certain viral families are common sources of outbreaks, predicting the specific virus within a family that will cause the next outbreak or pandemic is not possible, creating an urgent nee...
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Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD

bioRxiv Jan 1, 2025
Flagellin is the protein monomer of the bacterial flagellum, which confers motility, allowing bacteria to reach their favored niches. Flagellin is highly conserved across bacterial species and thus the target of the innate immune receptor Toll-like r...
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Growth Cost and Transport Efficiency Tradeoffs Define Root System Optimization Across Varying Developmental Stages and Environments in Arabidopsis

bioRxiv Jan 1, 2025
Root system architecture (RSA) is central to plant adaptation and fitness, yet the design principles and regulatory mechanisms connecting RSA to environmental adaptation are not well understood. We developed Ariadne, a semi-automated software for qua...
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CAPTAIN: A multimodal foundation model pretrained on co-assayed single-cell RNA and protein

bioRxiv Jan 1, 2025
Proteins act as the terminal effectors of cellular function, encoding the phenotypic consequences of genomic and transcriptomic programs. Although transcriptomic profiles serve as accessible proxies, they remain incomplete surrogates for the proteomi...
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Exploring neural manifolds across a wide range of intrinsic dimensions

bioRxiv Jan 1, 2025
Recent technical breakthroughs have enabled a rapid surge in the number of neurons that can be simultaneously recorded, calling for the development of robust methods to investigate neural activity at a population level. In this context, it is becomin...
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Intrinsic noise reveals the stability of a neuronal network

bioRxiv Jan 1, 2025
The stability of rhythmic activity in neural networks is an important aspect in the study of central pattern generators (CPGs). Different from other physiological rhythms, the activity of CPGs has not been fully characterized in terms of its stabilit...
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ANABAG: Annotated Antibody Antigen dataset with unique features for Antibody Engineering Applications

bioRxiv Jan 1, 2025
The analysis and prediction of antibody–antigen (Ab–Ag) interactions often overlook critical structural features such as glycosylation, physical chemical conditions like pH and salt concentration, as well as the lack of standardized criteria for sele...
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Mapping and reprogramming human tissue microenvironments with MintFlow

bioRxiv Jan 1, 2025
Tissue microenvironments reprogram local cellular states in disease, yet current computational spatial methods remain descriptive and do not simulate tissue perturbation. We present MintFlow, a generative AI algorithm that learns how the tissue micro...
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Functional Connectome of Superagers Reveals Early Markers of Resilience and Vulnerability to Alzheimer’s Disease

bioRxiv Jan 1, 2025
As populations age, identifying the neurobiological basis of cognitive resilience is critical for delaying or preventing Alzheimer’s disease (AD). While most older adults experience memory decline, a subset known as superagers (SA) maintains youthful...
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OmniPert: A Deep Learning Foundation Model for Predicting Responses to Genetic and Chemical Perturbations in Single Cancer Cells

bioRxiv Jan 1, 2025
In cancer, intra- and inter-patient heterogeneity presents a significant challenge for therapeutic management, as patients with apparently similar profiles often exhibit divergent responses to the same therapies. This heterogeneity is primarily attri...
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