High-throughput tracking yields rich time-series data of animal behaviour, yet extracting biological insight remains a bottleneck, even for simple control--treatment comparisons. Existing analyses struggle to pinpoint the multiple, nonlinearly intert...
Zoonotic influenza A viruses pose constitute a significant persistent threat to global public health, yet quantitative approaches for assessing their cross-species transmission potential remain limited. Here, we present InfluProto, a deep learning mo...
Inflammatory activation remodels the Golgi apparatus to meet increased secretory demand, yet whether these structural changes carry computationally accessible information about immune cell state has not been explored. Here we show that machine learni...
Parkinson's disease (PD) gait is characterized by reduced walking speed, short shuffling steps, increased double stance time, and increased step time variability. The most debilitating symptom in PD is freezing of gait (FOG), a context-dependent loco...
Fluorescence microscopy is a central tool in biomedical image analysis, but its practical use is often constrained by incomplete and heterogeneous data. This is especially true in rare disease research, where patient cohorts are small, biological mat...
Over the past decade, aptamers have emerged as promising therapeutics, with cancer therapeutics as a major research area. Existing computational methods, however, either predict aptamer-target pairs or design aptamers against a specific target. In th...
Humans adapt to changing environments by understanding the latent causal structure of events, and modern large language models (LLMs) increasingly exhibit analogous abilities. However, elucidating how causal knowledge is represented and integrated in...
Summary: Mass spectrometry resolution of glycosphingolipids requires advanced separation methods. The virtual-ly identical structures of glycolipid epimers cannot be discriminated by routine multiple reaction monitoring-high-performance liquid chroma...
Achieving near-single-cell precision in the prospective identification of long-term engrafting hematopoietic stem cells (LT-HSCs) remains challenging, likely because current static, point-in-time single-cell phenotyping technologies do not capture th...
Alterations in impulsivity characterize several neuropsychiatric disorders, however the neural processes that underlie an impulsive choice have not been identified. A recent body of literature suggests that there may be generalizable aspects of neura...
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