bioRxiv

Showing 3241 to 3250 of 4993 articles

Risking your Tail: Modeling Individual Differences in Risk-sensitive Exploration using Bayes Adaptive Markov Decision Processes

bioRxiv Jan 1, 2025
Novelty is a double-edged sword for agents and animals alike: they might benefit from untapped resources or face unexpected costs or dangers such as predation. The conventional exploration/exploitation tradeoff is thus coloured by risk-sensitivity. A...
View on bioRxiv DOI

Dental Age Assessment of White-tailed Deer via Computer Vision and Deep Learning

bioRxiv Jan 1, 2025
Accurate age estimation of white-tailed deer remains challenging for wildlife management, with existing computer vision methods limited to trail camera imagery and manual dental analysis requiring specialized expertise. This research presents the fir...
View on bioRxiv DOI

AVDB: The Arab Variation and Disease Burden Database

bioRxiv Jan 1, 2025
Public genomic databases are crucial to precision medicine but often lack representation from Arab populations, which have distinct genetic structures due to high consanguinity rates. We present the Arab Variation and Disease Burden Database (AVDB), ...
View on bioRxiv DOI

VASCilia (Vision Analysis StereoCilia): A Napari Plugin for Deep Learning-Based 3D Analysis of Cochlear Hair Cell Stereocilia Bundles

bioRxiv Jan 1, 2025
Cochlear hair cells are essential for hearing, and their stereocilia bundles are critical for mechanotransduction. However, analyzing the 3D morphology of these bundles can be challenging due to their complex organization and the presence of other ce...
View on bioRxiv DOI

Effects of the Neutral CB1 Receptor Antagonist AM6527 on Spontaneous, Consummatory, and Motivated Behavior in Mice

bioRxiv Jan 1, 2025
The cannabinoid type-1 receptor (CB1R) signaling pathway plays a central role in regulating motivational and feeding behaviors. Neutral CB1R antagonists represent a promising therapeutic class with potentially fewer adverse effects than inverse agoni...
View on bioRxiv DOI

Prompt-Driven Target Identification: A Multi-Omics and Network Biology Case Study of PARP1 Using Swalife PromptStudio

bioRxiv Jan 1, 2025
Artificial intelligence–assisted scientific prompting is reshaping how biological targets can be rapidly identified and contextualized. In this work, we present the Swalife PromptStudio – Target Identification workflow and illustrate its application ...
View on bioRxiv DOI

Evaluation of De Novo Deep Learning Models on the Protein-Sugar Interactome

bioRxiv Jan 1, 2025
Advances in deep learning have produced a range of models for predicting the protein-sugar interactome; however, structural docking of noncovalent protein-carbohydrate complexes remains largely unexplored. Although all-atom structure prediction model...
View on bioRxiv DOI

JointMap identified SERPINA3+ chondrocytes as a therapeutic target for osteoarthritis

bioRxiv Jan 1, 2025
Osteoarthritis (OA) is a prevalent degenerative joint disease that affects nearly half of the population aged over 65. Recent single-cell transcriptional studies have identified heterogeneous OA-specific chondrocyte subtypes, yet a unified subtype-cl...
View on bioRxiv DOI

Modelling Discrete States and Long-Term Dynamics in Functional Brain Networks

bioRxiv Jan 1, 2025
Functional brain network dynamics underlie fundamental aspects of human cognition and behaviour, including memory, ageing, and a range of clinical disorders. It has been shown that ongoing brain network dynamics can be reliably inferred at fast, sub-...
View on bioRxiv DOI

KM-GPT: An Automated Pipeline for Reconstructing Individual Patient Data from Kaplan–Meier Plots

bioRxiv Jan 1, 2025
Reconstructing individual patient data (IPD) from Kaplan–Meier (KM) plots provides valuable insights for evidence synthesis in clinical research. However, existing approaches often rely on manual digitization, which is error-prone and lacks scalabili...
View on bioRxiv DOI
Popular Topics
Popular Journals