bioRxiv

Showing 3301 to 3310 of 5001 articles

Small Molecule Approach to RNA Targeting Binder Discovery (SMARTBind) Using Deep Learning Without Structural Input

bioRxiv Jan 1, 2025
Accurate identification of small molecule binders to RNA is critical for chemical probes and therapeutics. Computational approaches offer a cost-effective strategy to identify small molecules targeting RNA but are often limited by poor predictive acc...
View on bioRxiv DOI

PathPCNet: Pathway Principal Component-Based Interpretable Framework for Drug Sensitivity Prediction

bioRxiv Jan 1, 2025
Precision medicine aims to identify significant biomarkers and effective drugs tailored to individual genomic profiles, thereby enabling personalized treatment strategies. Drug efficacy is often attributed to drug response, commonly measured as the c...
View on bioRxiv DOI

Data-efficient protein mutational effect prediction with weak supervision by molecular simulation and protein language models

bioRxiv Jan 1, 2025
Machine learning-based protein mutational effect prediction is widely used in protein engineering and pathogenicity prediction, but training data scarcity remains a major challenge due to high costs of experimental measurements. A previous study prop...
View on bioRxiv DOI

Single-cell transcriptomics and machine learning reveal RNF144B and C5AR1 as immune-related biomarkers and therapeutic targets in myocardial infarction

bioRxiv Jan 1, 2025
Myocardial infarction (MI) is a life-threatening cardiovascular disease characterized by high morbidity and mortality. Although advances in clinical management have improved patient outcomes, early diagnosis and effective immunomodulatory therapies r...
View on bioRxiv DOI

Benchmarking large language models for genomic knowledge with GeneTuring

bioRxiv Jan 1, 2025
Large language models (LLMs) show promise in biomedical research, but their effectiveness for genomic inquiry remains unclear. We developed GeneTuring, a benchmark consisting of 16 genomics tasks with 1,600 curated questions, and manually evaluated 4...
View on bioRxiv DOI

T-cell receptor specificity landscape revealed through de novo peptide design

bioRxiv Jan 1, 2025
T-cells play a key role in adaptive immunity by mounting specific responses against diverse pathogens. An effective binding between T-cell receptors (TCRs) and pathogen-derived peptides presented on Major Histocompatibility Complexes (MHCs) mediate a...
View on bioRxiv DOI

An Open-Source Deep Learning-Based Toolbox for Automated Auditory Brainstem Response Analyses (ABRA)

bioRxiv Jan 1, 2025
Hearing loss is a pervasive global health challenge with profound impacts on communication, cognitive function, and quality of life. Recent studies have established age-related hearing loss as a significant risk factor for dementia, highlighting the ...
View on bioRxiv DOI

High-throughput virus quantification using cytopathic effect area analysis by deep learning

bioRxiv Jan 1, 2025
Traditional infectivity-based virion quantification methods, such as 50% tissue culture infectious dose (TCID50) and plaque assays, are typically performed in 6-, 12-, 24-, or 48-well cell culture plates and require manual work and analysis based on ...
View on bioRxiv DOI

RAVEN: Robust, generalizable, multi-resolution structural MRI upsampling using Autoencoders

bioRxiv Jan 1, 2025
Due to their high inter-tissue contrast, Magnetic resonance images (MRIs) can reflect neuroanatomical changes related to healthy aging and pathological processes. However, standard brain MRI acquisition resolutions hinder the ability to measure the m...
View on bioRxiv DOI

Short Oxygen Pulses Enhance Creative Problem-Solving

bioRxiv Jan 1, 2025
Creativity is central to human innovation, yet it often fluctuates from moment to moment. Identifying simple interventions to reliably boost creativity has broad scientific and societal value. Here, we tested whether short-pulse oxygen inhalation enh...
View on bioRxiv DOI
Popular Topics
Popular Journals