AIMC Journal:
bioRxiv

Showing 331 to 340 of 4935 articles

RECON infers regions of interest from H&E images and reconstructs whole-slide molecular profiles at single-cell resolution

bioRxiv Sep 1, 2026
Spatial omics technologies resolve molecular expression and spatial architecture at single-cell resolution, but profiling whole slides remains costly. In practice, only a few regions of interest (ROIs) are profiled, leaving the rest of the tissue unm...
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Function-driven geometry directs human pilosebaceous unit development

bioRxiv Sep 1, 2026
Single-cell technologies have generated cell censuses of tissues, however, how tissue geometry reflects functional needs remains poorly characterized. The human pilosebaceous unit offers a tractable model, a prenatally-formed complex mini-organ combi...
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Calibration-free compression brings Evo 2 to its full million-token context on a single GPU

bioRxiv Sep 1, 2026
Evo 2 is the largest openly available genomic foundation model, but its forty billion parameter configuration cannot be loaded onto a single 80 GB accelerator, placing genome-scale analysis beyond most laboratories. We present TurboQuant-Bio, an open...
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Intelligent differential ion mobility spectrometry (iDMS): A deep neural network that predicts optimal space-resolved ion mobility parameters for isomeric monoglycosphingolipids

bioRxiv Sep 1, 2026
Simultaneous quantification of monoglycosphingolipid stereoisomers is required to monitor changes in defective enzymatic pathways linked to diseases such as Gaucher Disease, Parkinson's Disease, and Krabbe Disease. Resolution of beta-glucosyl and bet...
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Abundant Glomerular Neutrophil Extracellular Traps in C3 Glomerulopathy

bioRxiv Sep 1, 2026
Introduction: C3 glomerulopathy (C3G) is driven by fluid-phase alternative complement pathway dysregulation, with emerging evidence linking glomerular neutrophil infiltration to disease severity. Neutrophil extracellular traps (NETs) are implicated i...
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Automatic bioinformatic software named entity recognition from literature

bioRxiv Sep 1, 2026
Bioinformatics software and databases are essential components of modern life science research, yet their mentions in the scientific literature are often inconsistent and difficult to systematically identify at scale. The lack of a comprehensive and ...
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TomatoPGFM: A graph-conditioned foundation model for tomato pangenomes

bioRxiv Sep 1, 2026
Most genomic foundation models are pretrained on independent linear assemblies and therefore do not explicitly represent population-level segment sharing or local graph connectivity. We developed TomatoPGFM, a graph-conditioned model pretrained on 54...
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From Public Archive to Reusable Resource: Characterizing Gut Microbiome Metadata in the NCBI SRA

bioRxiv Sep 1, 2026
Public sequencing repositories contain large amounts of gut microbiome data that could support cross-study comparison, reproducibility analysis, and microbiome foundation model development. However, the extent to which these data are structured, harm...
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TigerAI: An AI-powered genetic evidence platform to support clinical development

bioRxiv Sep 1, 2026
Genetic evidence is a major determinant of clinical success in drug development, yet its aggregation has long relied on laborious human curation. Large language models (LLMs) have the potential to rapidly synthesize knowledge across biomedical resour...
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CREST: A Cortical Resting-State EEG Spatial Transformer for Chronic Pain Inference

bioRxiv Sep 1, 2026
Chronic pain mechanisms are complex, spanning multiple brain regions and networks. We ask whether resting brain activity carries a readout of that state. From a few minutes of resting-state electroencephalography (EEG), we generate a spectrogram to r...
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