bioRxiv

Showing 3421 to 3430 of 5001 articles

Geographical origin and cultivar differentiation of Kava (Piper methysticum) using Artificial Neural Network with FTIR Spectroscopy: A Novel Method

bioRxiv Jan 1, 2025
This study presents a novel method for authenticating the geographical origin and cultivar of kava (Piper methysticum) by combining Fourier Transform Infrared (FTIR) spectroscopy with Artificial Neural Networks (ANN). A spectral database of kava vari...
View on bioRxiv DOI

Natural gradient Bayesian sampling automatically emerges in canonical cortical circuits

bioRxiv Jan 1, 2025
Accumulating evidence suggests the canonical cortical circuit, consisting of excitatory (E) and diverse classes of inhibitory (I) interneurons, implements Bayesian posterior sampling. However, most of the identified circuits’ sampling algorithms are ...
View on bioRxiv DOI

MetaboFM: A Foundation Model for Spatial Metabolomics

bioRxiv Jan 1, 2025
Mass spectrometry imaging (MSI) provides molecularly resolved maps of metabolites and lipids across tissues, yet the lack of large-scale, unified representation learning frameworks limits its potential for generalization and downstream analysis. Here...
View on bioRxiv DOI

Generative enhancement of non-invasive dataset for motor brain-computer interface by task-relevant neural signals

bioRxiv Jan 1, 2025
Despite the increasing adoption of deep neural networks (DNNs) in brain-computer interfaces (BCIs), developing high-degree-of-freedom (DOF) systems capable of decoding continuous movements, such as limb kinematics, remains a significant challenge. Th...
View on bioRxiv DOI

Biophysical network modeling of temporal and stereotyped sequence propagation of neural activity in the premotor nucleus HVC

bioRxiv Jan 1, 2025
Stereotyped neural sequences are often exhibited in the brain, yet the neurophysiological mechanisms underlying their generation are not fully understood. Birdsong is a prominent model to study such behavior particularly because juvenile songbirds pr...
View on bioRxiv DOI

Structurally Informed Fitness Landscapes for Surveillance of Emerging PRRSV Variants

bioRxiv Jan 1, 2025
Antibodies play a central role in neutralizing pathogens through direct interference with viral entry and recruitment of effector immune cells. However, viruses employ sophisticated escape mechanisms to evade these defenses, primarily through mutatio...
View on bioRxiv DOI

Segmentation-guided photon pooling enables robust single cell analysis and fast fluorescence lifetime imaging microscopy

bioRxiv Jan 1, 2025
Fluorescence lifetime imaging microscopy (FLIM) can probe the metabolic environment of living cells in a label-free and non-invasive manner. However, endogenous fluorophores have low absorption and quantum yields, which necessitates long integration ...
View on bioRxiv DOI

StoPred: Accurate Stoichiometry Prediction for Protein Complexes Using Protein Language Models and Graph Attention

bioRxiv Jan 1, 2025
Proteins often function as part of complexes, and the specific stoichiometry of these assemblies is critical for their biological roles, but experimental determination of assembly composition remains challenging and existing computational methods for...
View on bioRxiv DOI

Multi-Class Classification of Cannabis and Alcohol Use Disorder: Identifying Common and Substance-Specific Neural Circuits

bioRxiv Jan 1, 2025
Machine learning approaches have advanced the identification of neural signatures of substance use, particularly through case-control comparisons and network-level analyses. However, most studies have focused on single substances in isolation, making...
View on bioRxiv DOI

Single-cell lineage trajectory defines CDK inhibitor-sensitive cells-of-origin in esophageal squamous cell cancer

bioRxiv Jan 1, 2025
Understanding the cells of origin is essential for overcoming therapy resistance in esophageal squamous cell carcinoma (ESCC). We utilized machine learning-based single-cell trajectory analysis on 4NQO-induced murine models and genetically engineered...
View on bioRxiv DOI
Popular Topics
Popular Journals