AIMC Journal:
bioRxiv

Showing 351 to 360 of 4935 articles

Cardiolipin increases the peak of reversible traveling H+ fronts at the membrane surface

bioRxiv Aug 31, 2026
Cardiolipin (CL) is a phospholipid found in the inner mitochondrial membrane (IMM) where it increases the efficiency of ATP regeneration. We have investigated the hypothesis that this increase may result in part from CL concentrating H+ at the IMM su...
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Genome-scale label-free imaging reveals cellular physiology encoded in bacterial collective architecture

bioRxiv Aug 31, 2026
DNA sequencing unified microbial genotyping into a single, comprehensive readout, yet phenotyping remains a slow and fragmented endeavor. Here, we introduce Microbial Phenotyping Using Low-magnification Label-free Imaging (PULLI), a computer vision p...
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Influence of neural network bursts on functional development

bioRxiv Aug 30, 2026
Network bursts or synchronized burst events are a typical activity seen in most in vitro neural networks. Network bursts arise early in development and as networks mature, activity becomes dominated by bursts propagating across the entirety of the ne...
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Vipsania: Unsupervised Deep Gene Finding

bioRxiv Aug 30, 2026
Scaling the structural annotation of protein-coding genes to all eukaryotic genomes remains a major challenge. While recent deep learning methods rival evidence-based pipelines without requiring RNA-seq or alignments, they are entirely supervised. Th...
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Structural generalization and continual learning enabled by factorized entorhinal-hippocampal memory and entorhinal-parietal action circuits

bioRxiv Aug 30, 2026
Flexible behavior requires generalizable memory and learning. For example, we rapidly learn to commute in new cities by reusing our knowledge of Euclidean two-dimensional space and structures like roundabouts and subway systems without forgetting how...
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PhageTransformer - scalable and accurate host assignments for bacteriophages

bioRxiv Aug 30, 2026
Bacteriophages can only be understood through their interactions with bacterial hosts. As environmental sequencing efforts expanded, the number of available phage genome sequences has exploded, yet the vast majority of these sequences lack host infor...
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Chemi-Proteome Language Attention Network Empowers Fragment-Based Ligand Interactome and Binding Sites Discovery with Evidence

bioRxiv Aug 30, 2026
Deep learning has accelerated drug discovery, yet most existing models are trained using in vitro affinity datasets and consequently remain disconnected from the cellular context in which functional ligand-protein interactions occur. This limitation ...
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CIViC-Fact: a proof-of-concept framework for AI-assisted verification of cancer variant interpretations

bioRxiv Aug 29, 2026
Accurate interpretation of genomic variants is critical for precision oncology but remains slow and dependent on specialized expertise. Public knowledgebases such as the Clinical Interpretation of Variants in Cancer (CIViC) help by curating literatur...
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Visual LLM-guided consensus spatial domain detection with L-STAR

bioRxiv Aug 29, 2026
Spatial domain detection is a central task in spatial transcriptomics, yet existing methods exhibit highly variable performance across datasets. We introduce L-STAR, a visual LLM-guided, consensus-based framework that leverages the visual reasoning c...
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Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome

bioRxiv Aug 28, 2026
Individuals with Down syndrome (DS) display developmental delay, intellectual disability, premature brain ageing, and an increased risk of Alzheimer-like neurodegeneration. Although the neuropathology of the postnatal and adult DS brain has been wide...
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