bioRxiv

Showing 3601 to 3610 of 5001 articles

Sensorimotor remapping drives task specialization in prefrontal cortex

bioRxiv Jan 1, 2025
The prefrontal cortex (PFC) plays a key role in flexible, context-dependent decision-making. Yet, the population-level mechanisms that support this flexibility remain unclear: is there a generalist neural population involved in representing useful in...
View on bioRxiv DOI

Computation or Weight Adaptation? Rethinking the Role of Plasticity in Learning

bioRxiv Jan 1, 2025
The human brain is an adaptive learning system that can generalize to new tasks and unfamiliar environments. The traditional view is that such adaptive behavior requires a structural change of the learning system (e.g., via neural plasticity). In thi...
View on bioRxiv DOI

AngleCam V2: Predicting leaf inclination angles across taxa from daytime and nighttime photos

bioRxiv Jan 1, 2025
Understanding how plants capture light and maintain their energy balance is crucial for predicting how ecosystems respond to environmental changes. By monitoring leaf inclination angle distributions (LIADs), we can gain insights into plant behaviour ...
View on bioRxiv DOI

TransStop, a genomic language model for the pan-drug prediction of translational readthrough efficacy

bioRxiv Jan 1, 2025
Premature termination codons (PTCs) are a major cause of genetic diseases, but the efficacy of therapeutic readthrough agents is highly context-dependent. While linear models have shown promise in predicting readthrough efficiency, they may not fully...
View on bioRxiv DOI

OmicsFUSION: A Pretrained Hyena-Based Framework for Encoding, Reconstruction, and Representation of the Omics and DNA Data

bioRxiv Jan 1, 2025
Recent advances in Natural Language Processing (NLP) have spurred the application of Large Language Models (LLMs) to bioinformatics, enabling innovative approaches to DNA sequence encoding. However, genomic function is not solely determined by the pr...
View on bioRxiv DOI

vcfsim: flexible simulation of all-sites VCFs with missing data

bioRxiv Jan 1, 2025
VCFs are the most widely used data format for encoding genetic variation. By design, standard VCFs do not include data from sites where all individuals are homozygous for the reference allele (“invariant sites”) and thus do not differentiate these fr...
View on bioRxiv DOI

Next generation neural mass model with dopamine modulation mediated by D1-type receptors

bioRxiv Jan 1, 2025
Neuromodulation is a complex process in which chemical substances modulate brain activity, allowing its rich repertoire of behaviors. Among these substances, dopamine has a preponderant role, being involved in several mechanisms. Moreover, dysfunctio...
View on bioRxiv DOI

Expanding the chemical exposome using in-silico transformation analysis – an example using insecticides

bioRxiv Jan 1, 2025
The exposome encompasses a vast chemical space that can originate from the consumer industry and environmental sources. Once these chemicals enter into cells (human or other organisms), they can be also transformed into products that differ in terms ...
View on bioRxiv DOI

OmniPath: integrated knowledgebase for multi-omics analysis

bioRxiv Jan 1, 2025
Analysis and interpretation of omics data largely benefit from the use of prior knowledge. However, this knowledge is fragmented across resources and often is not directly accessible for analytical methods. We developed OmniPath (https://omnipathdb.o...
View on bioRxiv DOI

Dynamic Gene Regulatory Network Inference with Interpretable, Biophysically-Motivated Neural ODEs

bioRxiv Jan 1, 2025
Gene Regulatory Networks (GRNs) are complex dynamical systems that modulate gene expression and drive transitions between phenotypic cell states. Determining these networks is crucial in understanding how gene dysregulation can lead to phenotypic var...
View on bioRxiv DOI
Popular Topics
Popular Journals