bioRxiv

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ZebraTrack: An Open-Source Object Detection Algorithm to Detect and Track Larval Zebrafish Motor Touch Responses

bioRxiv Jan 1, 2025
Zebrafish (Danio rerio) are a model organism used for the study of vertebrate development, disease and drug discovery. Two-day old larval zebrafish exhibit burst swimming behaviour that can be elicited by a light touch to the tail. Larval motor touch...
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Synaptic and potential fluctuations drive representational drift with differential effects on discrimination learning

bioRxiv Jan 1, 2025
Large-scale neuronal measurements have revealed continual drift of neural representations without explicit learning, raising fundamental questions about how the brain maintains reliable perception. While representational drift has been studied both e...
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A groove brain-music interface for enhancing individual experience of urge to move

bioRxiv Jan 1, 2025
When we listen to music, we often feel a pleasurable urge to move to music, known as groove. While previous studies have identified musical features that contribute to the groove experience, such as syncopation and tempo, they also report individual ...
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Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells

bioRxiv Jan 1, 2025
In hematology/oncology clinics, molecular diagnostics based on nucleic acid sequencing or hybridization are routinely employed to detect malignancy-associated genetic mutations and are instrumental in therapeutic stratification and prognostication. H...
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The alternated brain states in resting state after immoral decisions

bioRxiv Jan 1, 2025
Immoral decisions, which engage both cognitive control and reward system, bring both cognitive and neural consequences. However, how dishonesty has an impact on the brain’s dynamic alterations is still unclear. In this work, we attempt to understand ...
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Targeted Enzymatic Fragmentation of Lipoprotein(a) via Kringle IV Domains: A Clearance-Enhancing Therapeutic Strategy for Cardiovascular Disease

bioRxiv Jan 1, 2025
Elevated lipoprotein(a) [Lp(a)] is an independent, genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD). Its unique apolipoprotein(a) [apo(a)] component contains variable Kringle IV (KIV) domain repeats that influence...
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RNA sequence design and protein–DNA specificity prediction with NA-MPNN

bioRxiv Jan 1, 2025
RNA sequence design and protein–DNA binding specificity prediction can both be framed as nucleic acid inverse-folding problems: finding the most likely nucleic acid sequences given a fixed three-dimensional structure of a nucleic acid or nucleic acid...
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Coenzyme A depletion causes antibiotic tolerance in Pseudomonas aeruginosa

bioRxiv Jan 1, 2025
The widespread use of antibiotics promotes both resistance and tolerance. While resistance enables bacterial growth in the presence of drugs, tolerance allows survival during treatment, generating persisters that seed relapse and promote resistance. ...
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Behavioral Time Scale Synaptic Plasticity (BTSP) endows binding of distributed representations with flexible retrieval options

bioRxiv Jan 1, 2025
Human reasoning depends on reusing pieces of information by binding them together in new ways, thereby “making infinite uses of finite means” (Alexander von Humboldt). Needed for that is a binding mechanism that enables fast composition and decomposi...
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Neural Activity Dynamics in Primate Cortex Across Consciousness Levels: Insights from High-Density Neuropixel Recording

bioRxiv Jan 1, 2025
This study investigates the anesthesia mechanisms induced by sevoflurane and how it modulates neural activity in the posterior parietal cortex (PPC) and prefrontal cortex (PFC) in Non Human Primates (NHPs) using high density Neuropixel probes. Spikin...
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