bioRxiv

Showing 4121 to 4130 of 5016 articles

A data-driven analysis of spatiotemporal cues and experience accumulation effects for pitch type prediction

bioRxiv Jan 1, 2025
Conventional sports anticipation studies have primarily relied on hypothesis-testing paradigms that target predetermined cues. However, such approaches risk overlooking unanticipated sources of predictive information. This study addresses this limita...
View on bioRxiv DOI

Convolutional neural network models describe the encoding subspace of local circuits in auditory cortex

bioRxiv Jan 1, 2025
Convolutional neural networks (CNNs) provide powerful models of neural sensory encoding, but their complexity makes it difficult to discern computations that support their performance. To address this limitation, we developed a linear-nonlinear subsp...
View on bioRxiv DOI

CompleteBin: A transformer-based framework unlocks microbial dark matter through improved short contig binning

bioRxiv Jan 1, 2025
Metagenomic binning is crucial for reconstructing microbial genomes from metagenomic sequencing samples. However, existing tools struggle in complex communities where short, low-abundance contigs predominate, thereby limiting the recovery of complete...
View on bioRxiv DOI

Identifying tissue states by spatial protein patterns related to chemotherapy response in triple-negative breast cancer

bioRxiv Jan 1, 2025
Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited targeted therapies and variable responses to conventional chemotherapy, influenced by intratumoral heterogeneity and complex tumor microenvironment (TME) interactions. Unde...
View on bioRxiv DOI

Neural signatures of associational cortex emerge in a goal-directed model of visual search

bioRxiv Jan 1, 2025
Animals actively engage with their environment to gather information, continuously shaping both their sensory input and behavior. Understanding this closed loop between perception and action remains a central challenge in neuroscience. A key example ...
View on bioRxiv DOI

Design of TCR-mimicking binders for pHLA with high potency

bioRxiv Jan 1, 2025
The rational design of high-specificity binders to peptide–HLA (pHLA) complexes remains a major challenge in personalized immunotherapy, particularly for shared neoantigens with single-point mutations. To address this, we have developed an integrated...
View on bioRxiv DOI

The promise of AlphaFold for gene structure annotation

bioRxiv Jan 1, 2025
As sequencing technology improves, more genomes become available. Most lack annotation, automated methods are error prone, and few genomes are ever manually curated due to time and cost. Protein structure prediction software may provide new angles fo...
View on bioRxiv DOI

Computational Characterization of Decision Making During Trans-saccadic Visual Perception

bioRxiv Jan 1, 2025
When sampling visual information from the environment, humans execute fast sequential saccadic eye movements and yet preserve stability in their visual percept. This ability relies on the continuous integration of external sensory information (e.g., ...
View on bioRxiv DOI

Effect of Large Language Models on P300 Speller Performance with Cross-Subject Training

bioRxiv Jan 1, 2025
Amyotrophic lateral sclerosis (ALS), a progressive neuromuscular degenerative disease, rapidly impairs communication within years of onset. This loss of communication necessitates assistive technologies to restore interaction and independence. One su...
View on bioRxiv DOI

Hypercholesterolemia Risk Prediction from Serum Metabolomics Using a Metabolic Pathway-Integrated Graph Neural Network

bioRxiv Jan 1, 2025
In this paper, we presents a new machine learning framework called the Metabolic Pathway Graph Neural Network (MP-GNN), aimed at predicting hypercholesterolemia risk based on serum metabolomics data. Many existing analytical frameworks for analyzing ...
View on bioRxiv DOI
Popular Topics
Popular Journals