bioRxiv

Showing 4451 to 4460 of 5021 articles

Sampling Function-Related Metastable States of Proteins With DASH

bioRxiv Jan 1, 2025
Rational discovery of function-specific protein modulators as well as activity-enhanced engineering proteins underscore the need to identify function-related metastable states (FMSs) of proteins. However, current experimental and computational method...
View on bioRxiv DOI

Connectome of a human foveal retina

bioRxiv Jan 1, 2025
The foveal retina is a primate specialization which presents a feasible site for obtaining a complete connectome of a human CNS structure. In the fovea, cells and circuits are miniaturized and compressed to densely sample the visual image at high res...
View on bioRxiv DOI

Orthographic training finetunes a neuronal letter position code in primate visual cortex

bioRxiv Jan 1, 2025
Reading is an acquired skill that enhances brain activity in human visual cortex and is thought to repurpose preexisting ventral visual circuitry for the fast parallel processing of letter strings. However, the neuronal code underlying position-invar...
View on bioRxiv DOI

DeepAden: An explainable machine learning method for predicting the substrate specificity of nonribosomal peptide synthetases

bioRxiv Jan 1, 2025
Microbial non-ribosomal peptides (NRPs) exhibit remarkable structural diversity and serve as valuable sources of lead compounds for clinical drug development. The biosynthesis of NRPs relies on non-ribosomal peptide synthetases (NRPSs), in which aden...
View on bioRxiv DOI

DeepRank-Ab: a scoring function for antibody-antigen complexes based on geometric deep learning

bioRxiv Jan 1, 2025
Gaining structural insights into the interactions between antibodies and their corresponding antigens is essential for understanding immune recognition and for guiding therapeutic antibody design. However, accurately modelling these complexes remains...
View on bioRxiv DOI

The footprint of colour in EEG signal

bioRxiv Jan 1, 2025
Our perception of the world is inherently colourful, and colour provides well-documented benefits for vision: it helps us see things quicker and remember them better. We hypothesised that colour is not only central to perception but also a rich, deco...
View on bioRxiv DOI

MOTLAB: A Weighted Multi-Omics Transfer Learning Approach to Mitigate Breast Cancer Racial Disparities

bioRxiv Jan 1, 2025
Breast cancer (BC) is a leading cause of cancer death among women in United States. Previous studies have indicated that Black American women have disproportionately higher mortality than non-Hispanic White American women. Existing studies have demon...
View on bioRxiv DOI

Queryome: Orchestrating Retrieval, Reasoning, and Synthesis across Biomedical Literature

bioRxiv Jan 1, 2025
The rapid expansion of biomedical literature has made comprehensive manual synthesis increasingly difficult to perform effectively, creating a pressing need for AI systems capable of reasoning across verified evidence rather than merely retrieving it...
View on bioRxiv DOI

Graph Neural Networks Model Based on Atomic Hybridization for Predicting Drug Targets

bioRxiv Jan 1, 2025
Accurate prediction of half-maximal inhibitory concentration (IC50) values is critical for accelerating drug discovery, yet traditional quantitative structure-activity relationship (QSAR) models often have limited ability to capture both local struct...
View on bioRxiv DOI

Redefining the topology of the human bone marrow using augmented spatial transcriptomic analysis

bioRxiv Jan 1, 2025
The bone marrow (BM) is the main site of haematopoiesis in adult life. Our understanding of the pathogenesis of BM-derived blood cancers is limited by lack of spatial contextualisation. While emerging spatial transcriptomic (ST) platforms offer unpre...
View on bioRxiv DOI
Popular Topics
Popular Journals