AIMC Journal:
bioRxiv

Showing 441 to 450 of 4935 articles

A Biologically Informed Heterogeneous Graph Neural Network for Multi-Task Prediction of ncRNA-Metastasis-Cancer Interactions

bioRxiv Aug 21, 2026
Metastasis involves context-dependent molecular interactions in which non-coding RNAs, particularly miRNAs and circRNAs, play important regulatory roles. However, existing computational approaches generally do not jointly represent cancer type, metas...
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Predicting VHH-Fc Developability from Large-Scale IgG Data

bioRxiv Aug 21, 2026
The VHH-Fc antibody scaffold is an emerging therapeutic modality. No public large-scale, standardized developability VHH-Fc dataset exists. Filling that gap, we introduce GDPa5, a 160-member VHH-Fc library profiled across 10 biophysical assays on the...
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RegFM: an interpretable context-aware foundation model for human transcriptional regulation

bioRxiv Aug 21, 2026
Transcriptional regulation is governed by interactions between cis-regulatory elements (CREs) and trans-acting regulators in a context-specific manner. Although DNA and single-cell foundation models have enabled modeling regulatory biology at scale, ...
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An AI System for Autonomous Algorithm Evolution in Drug Development

bioRxiv Aug 20, 2026
Artificial intelligence (AI) is increasingly permeating the drug development pipeline. Numerous algorithms for accelerating this multi-stage and multi-task process have been constructed, which depends heavily on expert design and labor-intensive task...
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Parametric neural control differentiates top neural network models of primate visual cortex

bioRxiv Aug 20, 2026
Leading deep neural network encoding models predict visual cortical responses with nearly indistinguishable accuracy, raising the strong inference that these models have converged on the same underlying brain-aligned parameterization of natural image...
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Placental derived Extracellular Matrix Supports multi-lineage cell attachment and nuclear remodeling revealed by quantitative imaging

bioRxiv Aug 20, 2026
Decellularized extracellular matrix (dECM) scaffolds are increasingly used in regenerative medicine, yet the extent to which processed placental dECM retains properties capable of influencing cellular responses remains unclear. This study combines fu...
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State-dependent aperiodic EEG dynamics track cortical network reorganization in chronic epilepsy

bioRxiv Aug 20, 2026
Aperiodic (1/f-like) EEG activity has rapidly become a popular noninvasive marker of cortical network state, proposed to index excitation-inhibition (E/I) balance and increasingly applied across neurological and psychiatric disorders. However, whethe...
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Cortical encoding of probabilistic temporal predictions during speech perception

bioRxiv Aug 20, 2026
The temporal structure of speech has traditionally been characterized by the rhythmicity of its canonical linguistic units (phonemes, syllables, words), each summarized by a mean occurrence rate. While valid, this view overlooks whether speech carrie...
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Biomarker Fidelity Score - A Quantitative Framework for Individual-Level Validation of Explainability Methods in 3D Alzheimer's Disease MRI Classification

bioRxiv Aug 20, 2026
Explainability methods applied to deep learning models for Alzheimer's disease neuroimaging produce attribution maps that vary substantially across methods and architectures, yet no validated quantitative framework exists for determining which method...
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Ancient human mitochondrial genomes encode antimicrobial peptides

bioRxiv Aug 20, 2026
Mitochondria are bacteria-derived organelles that coordinate major innate immune pathways, but whether mitochondrial genomes themselves encode direct antimicrobial functions is underexplored. Here, we test the hypothesis that ancient human mitochondr...
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