bioRxiv

Showing 4531 to 4540 of 5021 articles

Improving nanobody structure prediction with self-distillation

bioRxiv Jan 1, 2025
Nanobodies are increasingly attractive therapeutic and biotechnological molecules, yet accurate structure prediction of their highly variable H-CDR3 loops remains a central challenge for machine learning models. Here, we investigate whether nanobody-...
View on bioRxiv DOI

OTRec: deep learning recommender for prospective druggable disease–target associations

bioRxiv Jan 1, 2025
OTRec is a deep learning recommender system that prospectively predicts druggable disease– target associations. Unlike methods that rely on manually aggregated evidence scores, OTRec employs a two-tower architecture to learn latent representations di...
View on bioRxiv DOI

Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation

bioRxiv Jan 1, 2025
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well understood and can be mitigated, the impact of foreig...
View on bioRxiv DOI

MAGNET: an all-in-one foundation model for cross-modal and cross-dimensional microscopic image restoration

bioRxiv Jan 1, 2025
The application of emerging Foundation models in current microscopy has remained limited due to task-specific model designs, strong modality dependence and insufficient robustness under complex degradations. Here, we introduce MAGNET (Microscopic All...
View on bioRxiv DOI

Multiple Partially Overlapping Neural Modules Orchestrate Conflict Processing

bioRxiv Jan 1, 2025
Cognitive conflict is a ubiquitous aspect of our daily life, yet its underlying neural mechanisms remain debated. Competing theories propose that conflict processing is governed by either a domain-general system, multiple conflict-specific modules, o...
View on bioRxiv DOI

Integrating Machine Learning with Musculoskeletal Simulation Improves OpenCap Video-Based Dynamics Estimation

bioRxiv Jan 1, 2025
Musculoskeletal dynamics influence the progression and rehabilitation of many movement-related conditions. However, accurately estimating whole-body dynamics using accessible tools, like smartphone video, remains challenging. Physics-based and machin...
View on bioRxiv DOI

Transition from plasticity to dynamics-based value update for meta-learning

bioRxiv Jan 1, 2025
Value computation is fundamental to the survival of animals. Classical models suggest value is stored in synaptic weight through plasticity whereas more recent theories propose that recurrent network dynamics can encode and update value independently...
View on bioRxiv DOI

Economic and Social Modulations of Innate Decision-Making in Mice Exposed to Visual Threats

bioRxiv Jan 1, 2025
When confronted by predators, animals make innate decisions with rapid reaction times—a trait shaped by natural selection to maximize survival. However, rapid reactions are effective only when grounded in accurate judgments and appropriate choices, w...
View on bioRxiv DOI

Sequence and structural determinants of efficacious de novo chimeric antigen receptors

bioRxiv Jan 1, 2025
Advances in generative protein design using artificial intelligence (AI) have enabled the rapid development of binders against heterogeneous targets, including tumor-associated antigens. Despite extensive biochemical characterization, these novel pro...
View on bioRxiv DOI

Integrative metabolome-genome analysis reveals the genetic architecture of metabolic diversity in sorghum grain

bioRxiv Jan 1, 2025
Cereal grains are fundamental to global food security and bioenergy production, yet the genetic and molecular bases of grain metabolic diversity remain unresolved. Sorghum, a climate-resilient C4 grass with exceptional tolerance to heat and drought s...
View on bioRxiv DOI
Popular Topics
Popular Journals