bioRxiv

Showing 4561 to 4570 of 5021 articles

Spacing effect improves generalization in biological and artificial systems

bioRxiv Jan 1, 2025
Generalization is a fundamental criterion for evaluating learning effectiveness, a domain where biological intelligence excels yet artificial intelligence continues to face challenges. In biological learning and memory, the well-documented spacing ef...
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DENDRO: Recovery and denoising of whole-tree dendritic voltage from 2D voltage movies

bioRxiv Jan 1, 2025
The ability to image voltage at high spatiotemporal resolution across an entire dendritic tree would represent a major advance in systems and circuit neuroscience. Recent advances in genetically encoded voltage indicators (GEVIs) have brought this po...
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Development of an AI Algorithm for Automatic Classification of Gram Stain Images in Microbiology

bioRxiv Jan 1, 2025
This paper reflects on the development and performance of an advanced artificial intelligence (AI) algorithm for the automated processing and classification of Gram stain images obtained from actual microbiology samples used in clinical microbiology....
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Sex differences in the neural circuitry of aggression

bioRxiv Jan 1, 2025
The social behavior neural network (SBNN) is a circuit composed of reciprocally connected limbic structures that regulate a range of social behaviors, including aggression. Although both males and females of many species display aggressive behavior, ...
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ELITE: E3 Ligase Inference for Tissue specific Elimination: A LLM Based E3 Ligase Prediction System for Precise Targeted Protein Degradation

bioRxiv Jan 1, 2025
Targeted protein degradation (TPD) has transformed modern drug discovery by harnessing the ubiquitin–proteasome system to eliminate disease-driving proteins previously deemed undruggable. However, current approaches predominantly rely on a narrow set...
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Unimeth: A unified transformer framework for accurate DNA methylation detection from nanopore reads

bioRxiv Jan 1, 2025
Nanopore sequencing has emerged as a powerful technology for DNA methylation detection, particularly in repetitive genomic regions and at the haplotype scale. However, existing computational methods show inconsistent accuracy across sequence contexts...
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Electrophysiological monitoring of plants: an exploratory study on drought stress

bioRxiv Jan 1, 2025
Climate change is increasing environmental stress, particularly rising temperatures and water scarcity, in both natural and human-managed systems such as agroecosystems and urban environments. Traditional methods for monitoring plant health in human-...
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Machine-learning-based determination of sex-related bladder cancer biomarkers

bioRxiv Jan 1, 2025
Bladder cancer exhibits sex-specific behavior, occurring more frequently in males but progressing to advanced stages more commonly in females. The activation of sex hormone receptors may explain these differences, but the exact genetic drivers remain...
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Automated detection and quantification of two-spotted spider mite life stages using computer vision for high-throughput in vitro assays

bioRxiv Jan 1, 2025
The two-spotted spider mite (Tetranychus urticae Koch) is a globally significant agricultural pest with high reproductive capacity, rapid development, and frequent evolution of miticide resistance. Breeding and selection of resistant host cultivars r...
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A META-ANALYSIS OF GUT MICROBIOME RESEARCH IN MALNOURISHED AFRICAN POPULATIONS: A NATURAL LANGUAGE PROCESSING APPROACH

bioRxiv Jan 1, 2025
Malnutrition still affects millions of children in Africa. Changes in the gut microbiome have been implicated in malnutrition, but there has been inconsistent nomenclature of microbes. This meta-analysis reviews the microbiome literature using natura...
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