bioRxiv

Showing 4601 to 4610 of 5021 articles

Response dynamics in macaque ventral stream recapitulate the visual hierarchy

bioRxiv Jan 1, 2025
Chronic recording in macaque inferotemporal cortex (IT) revealed a progression of feature selectivity over the duration of the response, with different images evoking strongest responses in different time bins. Neurons responded briskly and transient...
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Deviation Error: assessing predictions for replicate measurements in genomics and beyond

bioRxiv Jan 1, 2025
A quantitative measurement can have variation, referred to here as measurement variation, which is a probability distribution. Machine Learning models typically produce a prediction corresponding to the mode of the measurement variation. The Deviatio...
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Rubisco is slow across the tree of life

bioRxiv Jan 1, 2025
Rubisco is the main gateway through which inorganic carbon enters the biosphere, catalyzing the vast majority of carbon fixation on Earth. This pivotal enzyme has long been observed to be kinetically constrained. Yet, this impression is based on kine...
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Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation

bioRxiv Jan 1, 2025
Programmable control of gene expression in specific cell types is essential for both basic discovery and therapeutic intervention, yet current strategies lack scalability across diverse cellular contexts. Here, we introduce SPICE (Splicing Proportion...
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Leveraging Disease Association Degree for High-Accuracy MicroRNA Target Prediction

bioRxiv Jan 1, 2025
MicroRNAs (miRNAs) regulate gene expression by binding to mRNAs, inhibiting translation, or promoting mRNA degradation. Accurate identification of functional miRNA-target interactions (MTIs), typically validated by methods like western blot or report...
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The Road Not Taken: Unsaid Word Alternatives are Represented in the Brain

bioRxiv Jan 1, 2025
Human language allows multiple ways to express the same thought, implying that several lexical alternatives may exist in parallel before a single word is spoken or heard. We test the multiple alternatives-co-activation hypothesis by combining high-de...
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Development of a metabolic signature of post-weaning diarrhoea in pigs

bioRxiv Jan 1, 2025
In the agricultural sector, antibiotics have been used to improve swine growth performance. This application is banned nowadays, due to increased risk of antibiotic resistance. In piglets this results in a higher prevalence of post-weaning diarrhoea,...
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Revealing the Paper Mill Iceberg: AI-Based Screening of Cancer Research Publications

bioRxiv Jan 1, 2025
To train and validate a machine learning model to distinguish paper mill publications from genuine cancer research articles, and to screen the cancer research literature to assess the prevalence of papers that have textual similarities to paper mill ...
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Increased levels of HAPLN2, which anchors dense extracellular matrix, in the hippocampus of APOE4 targeted replacement mice

bioRxiv Jan 1, 2025
Hyaluronan and proteoglycan link protein 2 (HAPLN2) / Brain link protein-1 (Bral1) is important for the binding of chondroitin sulfate proteoglycans (CSPGs) to hyaluronan and thus for the formation of specific types of brain extracellular matrix (ECM...
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HyperBind2: Multi-Shot Learning Enables Progressive Improvement in Computational Antibody Discovery

bioRxiv Jan 1, 2025
Antibody discovery remains constrained by resource-intensive experimental screening approaches that offer limited control over critical properties. Here we present HyperBind2, a machine learning platform that progressively improves antibody-antigen i...
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