bioRxiv

Showing 4611 to 4620 of 5021 articles

Deep learning methods for automated bone segmentation and biomechanical modelling in zebrafish

bioRxiv Jan 1, 2025
Automated segmentation of three-dimensional micro-CT scans is critical for advancing morphometric and biomechanical approaches in musculoskeletal research. In the past decade, the ability to generate and access micro-CT data has increased significant...
View on bioRxiv DOI

Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation

bioRxiv Jan 1, 2025
Cell state transitions underlie the emergence of diverse cell types and are traditionally defined by changes in gene expression. Yet these transitions also involve coordinated shifts in cell morphology and behaviour, which remain poorly characterized...
View on bioRxiv DOI

Interventionally-guided representation learning for robust and interpretable AI models in cancer medicine

bioRxiv Jan 1, 2025
Machine learning models hold promise in cancer medicine but often lack robustness and interpretability. We introduce a new class of model for high-dimensional molecular data that incorporate interventional auxiliary information to learn latent repres...
View on bioRxiv DOI

Pre-movement neural population activity in human motor cortex reflects the subsequent outcome of futsal free kicks

bioRxiv Jan 1, 2025
Recent sports science studies suggest that optimizing neural activity can enhance motor performance, but practical applications have been hindered by large-scale electroencephalography (EEG) setups and controlled laboratory protocols. In our study, w...
View on bioRxiv DOI

Stress Coping Style Alters Functional Brain Network Activity to Acute Stressor

bioRxiv Jan 1, 2025
Consistent individual differences in behavior (e.g., personality types, stress coping styles) are a common occurrence across animal taxa. One hypothesis poses that the resulting constraints for within-individual behavioral variation may also lead to ...
View on bioRxiv DOI

gffutilsAI: an AI-agent for interactive genomic feature exploration in GFF files

bioRxiv Jan 1, 2025
The General Feature Format (GFF) is widely used to represent genomic annotations, but its hierarchical, multi-attribute structure makes manual querying and analysis challenging. Existing libraries such as gffutils provide programmatic interfaces, yet...
View on bioRxiv DOI

Interpretable Aging Signatures in Human Retinal Cell Types Revealed by Single-Cell RNA Sequencing and Sparse Logistic Regression

bioRxiv Jan 1, 2025
To characterize cell type specific transcriptional changes during human retinal aging and develop machine learning model for cellular age discrimination in a Chinese cohort. Cross-sectional, laboratory-based observational study. Eighteen unfrozen ret...
View on bioRxiv DOI

Multimodal AI for Single cfDNA Profiling and Cancer Screening

bioRxiv Jan 1, 2025
Cell-free DNA (cfDNA) serves as a non-invasive biomarker for cancer detection, but conventional methods face challenges due to the ultra-low abundance of tumor-derived cfDNA (ctDNA) among normal cfDNA. Though nucleosome-bound cfDNA harbors rich epige...
View on bioRxiv DOI

Template-based RNA structure prediction advanced through a blind code competition

bioRxiv Jan 1, 2025
Automatically predicting RNA 3D structure from sequence remains an unsolved challenge in biology and biotechnology. Here, we describe a Kaggle code competition engaging over 1700 teams and 43 previously unreleased structures to tackle this challenge....
View on bioRxiv DOI

Morphometry-based detection of deep learning faults in glomerular segmentation

bioRxiv Jan 1, 2025
Deep learning-based segmentation has evolved to a powerful strategy for automatically annotating glomeruli in kidney biopsy images. However, since any artificial intelligence can make mistakes, strategies for identifying and correcting faulty annotat...
View on bioRxiv DOI
Popular Topics
Popular Journals