bioRxiv

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Facial photographs as proxies for inflammatory aging

bioRxiv Jan 1, 2025
Systemic chronic inflammation is a major determinant of aging and disease risk, yet current biomarkers such as the Inflammatory Age (iAge) clock and other proteomic assays remain costly, invasive, and poorly scalable. The skin, as both a visible mark...
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Structural constraints acting on the SARS-CoV-2 spike protein reveal limited space for viral adaptation

bioRxiv Jan 1, 2025
The SARS-CoV-2 pandemic resulted in an unprecedented scientific response. The enormous scale of global genome sequencing, protein structural determination and targeted studies of protein and variant dynamics has resulted in a unique dataset which pro...
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REM sleep predicts reductions in pathophysiological daytime basal ganglia-cortical circuit activity in Parkinson’s disease

bioRxiv Jan 1, 2025
Sleep disturbances have been shown to be intimately and bidirectionally related to disease progression across a wide range of neurodegenerative disorders including Parkinson’s disease (PD) and Alzheimer’s disease. However, the precise neurophysiologi...
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CIViC MCP: Integrating Large Language Models with the Clinical Interpretations of Variants in Cancer

bioRxiv Jan 1, 2025
The Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase provides a community-driven, open-source platform for discussing the biological and Clinical Significance of molecular variants in cancer. To enable users to make complex connect...
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Functional Connectivity-based Attractor Dynamics in Rest, Task, and Disease

bioRxiv Jan 1, 2025
Functional brain connectivity has been instrumental in uncovering the large-scale organization of the brain and its relation to various behavioral and clinical phenotypes. Understanding how this functional architecture relates to the brain’s dynamic ...
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Learning neural dynamics through instructive signals

bioRxiv Jan 1, 2025
Rapid learning is essential for flexible behavior, but its basis in the brain remains unknown. Here we introduce the PRISM plasticity rule, a unifying mechanistic model of three well-established, fast-acting synaptic plasticity rules—in hippocampus, ...
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Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex

bioRxiv Jan 1, 2025
Activity-based protein profiling has identified hundreds of proteins from diverse classes that react at specific cysteine residues with stereochemically defined electrophilic compounds (stereoprobes) in human cells. The structure-activity relationshi...
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A validated set of neural gene reporter mice and chemical tracers tools for mapping knee innervating neurons

bioRxiv Jan 1, 2025
Joint pain is an increasing concern for our aging population, as current therapies to slow joint disease progression or reduce pain are largely ineffective and often carry significant health and dependency risks. Age and joint disease induce changes ...
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A dual information seeking strategy improves imprecise human inferences outside the explore–exploit tradeoff

bioRxiv Jan 1, 2025
Everyday decisions require not just earning rewards but also learning about the world. We asked how people gather information when sampling is reward free, and compared this with reward seeking under identical outcome distributions. In a large study ...
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Optimized feature gains explain and predict successes and failures of human selective listening

bioRxiv Jan 1, 2025
Attention facilitates communication by enabling selective listening to sound sources of interest. However, little is known about why attentional selection succeeds in some conditions but fails in others. While neurophysiology implicates multiplicativ...
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