bioRxiv

Showing 4901 to 4910 of 5021 articles

SIMAIS: A swarm intelligence inspired biosensor for rapid protein detection

bioRxiv Jan 1, 2025
Swarm intelligence, the collective behaviour of animals such as birds, fish, and ants, arises from simple local interactions and enables survival, efficient foraging, and decision-making without central control. Inspired by this principle, we aimed t...
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Separable neurocomputational mechanisms underlying multisensory learning

bioRxiv Jan 1, 2025
Efficient control of behavior requires multisensory learning from information distributed across senses. However, most neurocomputational studies have focused on unisensory signals. Here, we identify distinct but interacting neurocomputational mechan...
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MORPH2DIAG: Automated Structural MRI Preprocessing and Tissue Segmentation for Interpretable Machine and Deep Learning-Based Neuroanatomical Classification

bioRxiv Jan 1, 2025
Structural MRI provides a noninvasive window into brain morphology, yet the reproducibility and interpretability of morphometric analyses remain limited by inconsistent preprocessing, variable spatial alignment, and heterogeneous feature construction...
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Traces of parenthood but not pregnancy loss in UK Biobank structural brain MRI data

bioRxiv Jan 1, 2025
Pregnancy induces neuroanatomical changes in the human brain. Earlier studies detected traces of motherhood decades after childbirth. It is unclear whether these reflect persisting traces of pregnancy or effects of parenthood. We investigated effects...
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Semantic-Aware Graph Embedding Approach Uncovers LC-61, a Potent Anti–Leishmania infantum Compound

bioRxiv Jan 1, 2025
Visceral leishmaniasis caused by Leishmania infantum remains a lethal disease with few therapeutic options, necessitating innovative computational methods approaches to accelerate drug discovery. Here, we present a semantic-aware graph neural network...
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Microđť•Šplit: Semantic Unmixing of Fluorescent Microscopy Data

bioRxiv Jan 1, 2025
Fluorescence microscopy, a key driver for progress in the life sciences, faces limitations due to the microscope’s optics, fluorophore chemistry, and photon exposure limits, necessitating trade-offs in imaging speed, resolution, and depth. Here, we i...
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Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation

bioRxiv Jan 1, 2025
Extracellular vesicles (EVs) mediate tumor-immune cell communication by carrying protein cargo that can immediately modulate signaling and antigen presentation. Yet mapping the uptake of primary EV proteomes by human immune cells at single-cell resol...
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Composing the value signal for dopamine-mediated learning

bioRxiv Jan 1, 2025
The seminal reward prediction error theory of dopamine function faces several key challenges. Most notable is the difficulty learning multiple rewards simultaneously, inefficient on-policy learning, and accounting for heterogeneous striatal responses...
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TSProm: Deciphering the Genomic Context of Tissue Specificity

bioRxiv Jan 1, 2025
Characterizing tissue-specific (TSp) gene expression is crucial for understanding development and disease; however, traditional expression-based methods often overlook the latent “regulatory grammar” embedded in the non-coding DNA, particularly in di...
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A unifying account of replay as context-driven memory reactivation

bioRxiv Jan 1, 2025
During rest and sleep, sequential neural activation patterns corresponding to awake experience re-emerge, and this replay has been shown to benefit subsequent behavior and memory. Whereas some studies show that replay directly recapitulates recent ex...
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