bioRxiv

Showing 4911 to 4920 of 5021 articles

Development and characterization of a scalable calcium imaging assay using human iPSC-derived neurons

bioRxiv Jan 1, 2025
Neuroscience drug discovery is challenged by the brain’s structural and cell-type complexity, which is difficult to model in cellular systems compatible with high-throughput screening methods. Calcium oscillation assays, that harness neurons’ intrins...
View on bioRxiv DOI

Fast and Easy Whole-Brain Network Model Parameter Estimation with Automatic Differentiation

bioRxiv Jan 1, 2025
Personalized brain modeling at clinically relevant scales requires integrating biophysical models with empirical neuroimaging data, yet high-dimensional parameter estimation in whole-brain network models remains computationally prohibitive. We presen...
View on bioRxiv DOI

CrossPPI: A Cross-Fusion Based Model for Protein–Protein Binding Affinity Prediction

bioRxiv Jan 1, 2025
Many biological processes depend on protein–protein interactions (PPIs), which are particularly important across biology, medicine, and biotechnology. It is essential to accurately predict the binding affinity between protein pairs to prioritize cand...
View on bioRxiv DOI

Skin lipid chemistry influences host-microbiome-pathogen interactions in snake fungal disease (ophidiomycosis)

bioRxiv Jan 1, 2025
Within host-microbiome-pathogen systems, the host chemical microenvironment is often overlooked despite its inherent role in host physiology. We used a multifaceted experimental approach encompassing culture-dependent and independent methods, metagen...
View on bioRxiv DOI

Unified modeling of cellular responses to diverse perturbation types

bioRxiv Jan 1, 2025
Predicting cellular responses to perturbations is essential for understanding gene regulation and advancing drug development. Most existing in silico perturbation models treat perturbation–cell interactions with simplistic fusion strategies that over...
View on bioRxiv DOI

Validation of deep learning enabled web based and smartphone optimized application RadAnalyzer to measure vertebral heart size and vertebral left atrial size in dogs

bioRxiv Jan 1, 2025
Objective radiographic measures of heart size including vertebral heart size (VHS) and vertebral left atrial size (VLAS) are associated with inter and intra-observer variability when measured by humans. Artificial intelligence (AI) tools including Ra...
View on bioRxiv DOI

TEIP: A Compact, Open-Source Framework for Predicting Tumor Epitope Immunogenicity in Glioblastoma Using Deep Learning and Multi-Modal Biological Features

bioRxiv Jan 1, 2025
This work introduces a modular, open-source computational pipeline for glioblastoma (GBM) vaccine design that integrates omics-based OIP5 target discovery with a deep learning framework for epitope immunogenicity prediction. Building upon conventiona...
View on bioRxiv DOI

Billion-Scale Deciphering of Human Gene Regulatory Grammar

bioRxiv Jan 1, 2025
Predicting how DNA sequence specifies gene expression remains a core challenge across regulatory genomics. Most predictive assays and models depend on native genomic DNA, constraining the full biochemical engineering space for assessing and designing...
View on bioRxiv DOI

MetaboliteChat: A Unified Multimodal Large Language Model for Interactive Metabolite Analysis and Functional Insights

bioRxiv Jan 1, 2025
Accurately characterizing the mechanisms and properties of metabolite molecules is essential for advancing metabolomics and systems biology. Yet most existing approaches are narrow, task-specific models that do not transfer across tasks and cannot ex...
View on bioRxiv DOI

Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

bioRxiv Jan 1, 2025
The current state of mental health treatment for individuals diagnosed with major depressive disorder leaves billions of individuals with first-line therapies that are ineffective or burdened with undesirable side effects. One major obstacle is that ...
View on bioRxiv DOI
Popular Topics
Popular Journals