AIMC Journal:
bioRxiv

Showing 601 to 610 of 4938 articles

MetaAMI: A Novel Meta-Learning Approach for Predicting In-Hospital Mortality in Acute Myocardial Infarction

bioRxiv Aug 1, 2026
Acute myocardial infarction (AMI) is one of the leading cardiovascular diseases worldwide and remains a major cause of mortality. Early risk prediction can help clinicians identify high risk patients shortly after admission and support timely monitor...
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SPINDLE: Unlocking protein dynamics from single-field NMR relaxation data using a deep learning ensemble.

bioRxiv Aug 1, 2026
A protein's function is derived from its three-dimensional structure and the motions of the atoms about that structure. The detailed characterization of both macromolecular structure and dynamics provides an opportunity for understanding enzyme catal...
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Metabolic brain networks switch between a sparsely connected baseline and highly integrated states to support cognition

bioRxiv Jul 31, 2026
The human brain achieves cognitive flexibility by rapidly switching between large-scale functional network states. While network state switching is assumed to be an energetically demanding process, the direct metabolic and neurochemical foundation un...
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Systematic modeling of phenotypic drug response profiles inpatient-derived organoids

bioRxiv Jul 31, 2026
Patient-derived tumor organoids provide a physiologically relevant 3D disease model for preclinical drug discovery, surpassing the limitations of conventional 2D cell lines. To better capture the dynamic nature of organoid drug responses, we develope...
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Striatal acetylcholine enables latent-state creation during reversal learning

bioRxiv Jul 31, 2026
Like dopamine, acetylcholine is modulated in the striatum by reward-predicting cues and outcomes, yet its computational role remains unclear. Here, we manipulated dorsomedial striatal acetylcholine in mice performing a reversal learning task using ge...
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Exploratory Network Analysis of Oral Bacteria Taste Signaling Autophagy Crosstalk in Oral Squamous Cell Carcinoma and Multi-Target Ligand Design for the MAPK1 STAT3 mTOR Axis

bioRxiv Jul 31, 2026
G protein-coupled receptor (GPCR) signaling represents a critical interface between oral bacteria and host cellular regulation in oral squamous cell carcinoma (OSCC). Here, we integrated systems biology, exploratory machine learning, and structure-ba...
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ATP-Free Fatty Aldehyde Biosynthesis Enables an Autonomous Lux-Based Bioluminescence System

bioRxiv Jul 31, 2026
Autonomous bioluminescence systems enable continuous light emission in engineered organisms by genetically encoding both luciferase enzymes and their substrate biosynthetic pathways, offering a powerful platform for non-invasive and long-term monitor...
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A curated human lactylome and protein language model framework enable accurate prediction and reveal local determinants of lysine lactylation

bioRxiv Jul 31, 2026
Lysine lactylation is a dynamic post-translational modification that can alter protein function and has been implicated in diverse physiological and pathological processes. Accurate identification of lactylation sites is therefore important for defin...
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CENO: A Genome-Scale World Model for Evolutionary Sequence Interpretation and Programmable Regulatory Design

bioRxiv Jul 30, 2026
DNA encodes biological function across a continuum of sequence scales, from single-nucleotide and motif-level grammar to regulatory neighborhoods, chromatin-scale organization and evolutionary constraint. A useful model of genomes should therefore do...
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LLM-powered Functional Gene Set Summarization with genesetGPT

bioRxiv Jul 30, 2026
Transcriptomics datasets generated using next-generation sequencing techniques such as single cell RNA-sequencing (scRNA-seq) and spatially-resolved transcriptomics (SRT) allow researchers to study patterns in gene expression across celltypes, tempor...
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