AIMC Journal:
bioRxiv

Showing 791 to 800 of 4938 articles

Rapid immunostaining and high-resolution three-dimensional light-sheet microscopy of intact calcified tissues

bioRxiv Jul 10, 2026
High-resolution 3D imaging is an important strategy for visualizing and analysing complex skeletal tissue architecture and the bone marrow microenvironment. However, multicolor immunolabeling and imaging of intact skeletal tissues are technologically...
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Monocyte-amplified transcriptional signatures of human diseases

bioRxiv Jul 10, 2026
Blood-based biomarkers discovered by machine learning often lack disease specificity and cross-population robustness for clinical applications. We describe a biomarker discovery strategy that exploits monocytes as circulating sentinels to amplify dis...
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Autonomous computational prioritisation of colorectal cancer vulnerabilities via multi-scale AI swarms

bioRxiv Jul 10, 2026
The acceleration of automated scientific discovery has been fundamentally bottlenecked by the epistemic gap between the semantic reasoning of large language models (LLMs) and the complex, non-linear reality of mammalian biology. While recent multi-ag...
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Rapidly evolving aphid gall effector proteins exhibit saposin-like folds

bioRxiv Jul 10, 2026
Many insects manipulate plants by injecting effector proteins. In one extreme example of this molecular "hijacking", Hormaphis cornu aphids inject bicycle proteins into Hamamelis virginiana, contributing to the development of novel organs called gall...
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Learning complex temporal dependencies via local synaptic plasticity

bioRxiv Jul 10, 2026
The ability to extract and exploit temporal structure across diverse tasks is central to human cognition. Neuroscientists have typically relied on recurrent neural networks (RNNs) trained with backpropagation through time (BPTT) when modelling neural...
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Synthesizing Mechanistic Hypotheses from Single-Cell Omics via Discretized Feature Attribution and Empirical Language Model Grounding

bioRxiv Jul 10, 2026
Single-cell multimodal omics offer unprecedented resolution of cellular networks, yet translating continuous computational attributions into structured, testable biological mechanisms remains a persistent bottleneck. To address this limitation, we in...
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Machine learning-assisted Repli-Histo labeling reveals distinct transcription-dependent constraints on chromatin motion in living cells

bioRxiv Jul 10, 2026
Genomic DNA is wrapped around core histones to form nucleosomes, which are organized in cells from euchromatin to heterochromatin with distinct genome functions. Although transcription is known to shape chromatin behavior in live cells, it remains un...
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Semantic fragment representations for coordinate-free analysis of genomics data

bioRxiv Jul 10, 2026
Many genomic assays begin with individual DNA fragments, but standard analysis quickly collapses those molecules into counts over genomic intervals. Rich information carried by each fragment, including its sequence, fragment body, cleavage boundaries...
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Computational design of de novo integrated domains enables rational control of pathogen effector recognition in plant NLR immune receptors.

bioRxiv Jul 10, 2026
The rapid evolution of plant pathogens poses a persistent threat to global agricultural sustainability, often outpacing the discovery and deployment of natural disease resistance genes. While bioengineering of plant intracellular immune receptors (NL...
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A metacognitive response of the face and the heart in rats

bioRxiv Jul 10, 2026
Humans make emotional facial expressions and have a cardiac response when they catch themselves in a mistake or receive feedback about task performance. We tested whether rats exhibit similar visceral responses in the context of metacognition. We ass...
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