AIMC Journal:
bioRxiv

Showing 891 to 900 of 4938 articles

Raw-count embeddings improve single-cell foundation models

bioRxiv Jul 3, 2026
Single-cell transformer foundation models have grown to hundreds of millions of parameters, yet the preprocessing choices that underlie them, including gene ranking and library-size normalisation, have not been systematically benchmarked. Testing sev...
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Unveiling Cerebrospinal Fluid Protein Biomarkers in Pediatric Acute Lymphoblastic Leukemia Using Proximity Extension Assay

bioRxiv Jul 3, 2026
Abstract Background: Acute Lymphoblastic Leukemia (ALL) is a highly heterogeneous pediatric malignancy. Despite high survival rates, relapse and the involvement of central nervous system (CNS) remains a significant clinical challenge. Traditional cli...
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Charge-trap flash memory cells of the brain

bioRxiv Jul 3, 2026
Despite extensive study of cellular mechanisms underlying long-term potentiation, no single specific protein or gene has been identified which encodes an individual unit of information, or memory bit. Indeed, the brain engram remains a knowledge gap....
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RD-OMICS: An Integrative Multi-Omics Data Inventory in Rare Diseases

bioRxiv Jul 3, 2026
Rare diseases (RD) impact over 30 million individuals in the United States, yet fewer than 5% of the identified conditions have FDA-approved treatments. Progress in RD research is hindered by small patient cohorts, biological heterogeneity, and the f...
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Age and Social Observation Effects on Theta Synchrony and Its Role in Adolescent Post-Error Control: A Computational Approach

bioRxiv Jul 3, 2026
Error monitoring allows for detecting mistakes and adapting behavior. Error monitoring is associated with increased theta (4-7 Hz) EEG activity recorded at midfrontal electrode sites located over the medial frontal cortex. Increases in theta synchron...
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Benchmarking the translational potential of AI-based drug-resistance prediction from Mycobacterium tuberculosis whole-genome sequencing data

bioRxiv Jul 3, 2026
Background: Tuberculosis, especially drug-resistant tuberculosis (DR-TB) including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, remains a leading cause of infectious death worldwide. The rapid accumulation of whole-genome s...
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SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program

bioRxiv Jul 3, 2026
S-acylation, the reversible addition of fatty acids to proteins, has emerged as an abundant post-translational modification that drives protein localization and function. With no known consensus sequence, current prediction programs rely on machine l...
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The human language processing system straightens natural speech

bioRxiv Jul 2, 2026
Large language models trained on next-word prediction have impressive linguistic capabilities. This suggests that the goal of temporal prediction is essential to language processing, but how this goal impacts the structure of speech representations i...
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A 3D Brain Geometry Toolkit for Multisite Neuroimaging Analysis

bioRxiv Jul 2, 2026
Compared to traditional gross volumetrics, surface- based models provide greater spatial precision for understanding brain alterations related to developmental, neurological, and psychiatric disorders. Large-scale brain initiatives are combining data...
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Reward predictability shapes decision making states and exploitative control in marmosets

bioRxiv Jul 2, 2026
Animals navigating dynamic environments must transition between behavioral states dominated by exploitation of known rewards or exploration of alternatives. Understanding this flexibility requires characterizing not only choices and outcomes but also...
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