AIMC Journal:
bioRxiv

Showing 921 to 930 of 4938 articles

Collective fluctuations underlying nanobody inhibitory activity targeting B. anthracis S-layers revealed by multiscale simulations

bioRxiv Jul 1, 2026
Nanobodies (Nbs) that depolymerize bacterial surface-layers (S-layers) offer a route to antivirulence therapeutics, but their mechanisms have been difficult to infer from binding structures alone. In B. anthracis, several Nbs bind to Sap, the S-layer...
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Nutrient-dependent hippocampus dopamine signaling enhances meal-related episodic memory and reduces food intake

bioRxiv Jul 1, 2026
Background: Dopamine (DA) is a neurotransmitter critically involved in food-related reinforcement learning. While mesolimbic DA reward-associated signaling in the nucleus accumbens has been widely investigated, far less is known about DA function in ...
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Revisiting the base pair maximization approach for RNA secondary structure prediction with SQUARNA

bioRxiv Jul 1, 2026
Non-coding RNAs play diverse roles in a wide range of cellular processes, with their spatial structure being pivotal to their function. RNA secondary structure is a key determinant of its overall fold. Given the scarcity of experimentally determined ...
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DDTRN: Predicting Bacterial Transcriptional Regulatory Networks Based on Gene Sequences using Dual Descriptor

bioRxiv Jul 1, 2026
Accurate computational reconstruction of bacterial transcriptional regulatory network (TRN) from sequence information alone remains a fundamental challenge in systems biology, particularly for non-model organisms lacking extensive transcriptomic data...
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GeneBench-Pro: Evaluating Multistage Statistical Reasoning\\in Genomics, Quantitative Biology, and Translational Biomedicine

bioRxiv Jun 30, 2026
We introduce GeneBench-Pro, an expanded and improved version of GeneBench that comprises harder problems across a wider breadth of domains. GeneBench-Pro is a benchmark for AI agents performing realistic multi-stage scientific analyses in genomics, q...
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Long-range inhibitory control of cholinergic network dynamics in the striatum.

bioRxiv Jun 30, 2026
Striatal cholinergic interneurons (CINs) exhibit a transient pause in tonic firing in response to salient stimuli, a hallmark of reinforcement learning that becomes synchronized with learning. Although thalamostriatal and dopaminergic inputs have bee...
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Spatial synaptic regularization stabilizes learning across biological and artificial neural networks

bioRxiv Jun 30, 2026
How the spatial organization of synapses contributes to stable learning remains a fundamental question in neuroscience. Using the H01 electron microscopy connectome of human temporal cortex, we found that dendritic spines clustered morphologically, w...
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Effects of gabapentin on ongoing behaviors displayed by mice with chemotherapy neuropathy

bioRxiv Jun 30, 2026
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and painful side effect of paclitaxel (PTX) treatment. The most common measures of painful neuropathy focus on evoked mechanical hypersensitivity, but clinically relevant ongoing pain rema...
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Impacts of batch effects on the performance of machine learning classifiers across multiple studies

bioRxiv Jun 30, 2026
Precision medicine relies on accurate and generalizable predictions for patients across the spectrum of human diversity. Because capturing biological heterogeneity requires large sample sizes, researchers must often aggregate data from several experi...
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Modelling individual ampullary afferents in two species of gymnotiform fish using simulation-based inference

bioRxiv Jun 30, 2026
Ampullary electroreceptors are widespread across aquatic vertebrates. The purpose of sensing exogeneous electric fields is conserved across species but the implementations differ and the encoding mechanisms remain incompletely understood. We compared...
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