AIMC Journal:
bioRxiv

Showing 931 to 940 of 4938 articles

Epigenetic signatures of infection within and across generations in the endangered Loggerhead sea turtle

bioRxiv Jun 30, 2026
Infection can substantially reduce host fitness and influence population dynamics, yet it is often difficult to detect and quantify in wild animal populations. Molecular tools offer a valuable means of identifying cryptic infection in natural systems...
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Integrating Semantic Retrieval, LLM-based Refinement, and Structured Expert Curation for Scalable AOP Gene Mapping

bioRxiv Jun 30, 2026
Toxicogenomics can support regulatory toxicology, but its use is limited by the difficulty of translating molecular responses into mechanistic, decision-relevant interpretations. Adverse Outcome Pathways (AOPs) provide a framework for this translatio...
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Retinal resuscitation in post-mortem eyes

bioRxiv Jun 30, 2026
Vision loss compromises the quality of life of millions of people worldwide. Currently, vision-restoring therapies are lacking. Post-mortem preservation of human eyes may enable whole eye transplantation (WET) or therapeutic development. We developed...
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A High-Quality Acetylation Dataset Reveals Modest Data Requirements for Transfer Learning to Identify Little Studied Post-Translational Modifications

bioRxiv Jun 30, 2026
Dysregulation of post-translational modifications (PTMs) is associated with severe pathologies, including cancers and Alzheimer's disease. Despite their biological importance, identifying modified peptides remains challenging due to the immense combi...
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Shared AI-brain control for reliable intracortical BCI navigation in dynamic environments

bioRxiv Jun 30, 2026
Intracortical brain-computer interfaces (iBCIs) can enable people with paralysis to control assistive devices, but reliable operation in dynamic environments remains limited by fluctuations in decoded neural commands. Here we develop a confidence-mod...
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CyStainer: A transformer-based variational autoencoder for robust marker imputation in high-parameter cytometry

bioRxiv Jun 30, 2026
High parameter cytometry is essential for clinical diagnostics through precise immune cell profiling, improved patient stratification, and monitoring, while also enhancing the understanding of cellular responses in disease and therapeutic contexts. T...
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Gene-level complexity explains genome-wide variation in the distribution of fitness effects

bioRxiv Jun 29, 2026
The distribution of fitness effects (DFE), describing how harmful, neutral, or beneficial new mutations are, is central to understanding how populations evolve. Although the DFE varies across genomes and species, it remains unclear which aspects of g...
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Incorporating Surfaced-Induced Dissociation Mass Spectrometry Data into an AlphaFold-derived deep learning network improves protein structure prediction

bioRxiv Jun 29, 2026
Surface-Induced Dissociation native Mass Spectrometry (SID-nMS) is a tandem MS activation method that yields information on the connectivity and stoichiometry of protein complexes. While insufficient for direct structure elucidation, the data derived...
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Self-Supervised Behavioral Representations Across the Life Course: A Killifish Case Study

bioRxiv Jun 29, 2026
Self-supervised foundation models of aging are increasingly built from longitudinal data (biobanks, electronic health records, wearables) that is inherently incomplete: no individual is followed across a whole lifetime, and how much of each life is c...
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Interpretable compositional computation with recurrent neural networks

bioRxiv Jun 29, 2026
Flexible cognition utilizes reusable components to enable rapid adaptation of behavior to different contexts or tasks. Analysis of artificial neural networks trained on multiple tasks suggested that this compositionality is supported by dynamical str...
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