AIMC Journal:
bioRxiv

Showing 951 to 960 of 4938 articles

Homology-aware cross-validation strategies for generalization assessment in RNA structure prediction

bioRxiv Jun 29, 2026
RNA secondary structure prediction is a fundamental challenge in bioinformatics, essential for understanding the functional roles of non-coding RNAs. Recently, deep learning models have transformed the field with impressive results, leading to critic...
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Neural correlates of evidence accumulation in social-affective decision-making under perceptual ambiguity

bioRxiv Jun 29, 2026
Evidence accumulation models have been widely used to explain decision-making in sensory and cognitive domains, but how this process explains social-affective decision-making under perceptual ambiguity remains unclear. Here, we integrate computationa...
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Pep2Mol: 3D Molecule Generation Targeting Protein-Protein Interfaces with Diffusion Models

bioRxiv Jun 29, 2026
Protein-protein interactions (PPIs) are central to biological processes. Designing small molecules that modulate dysregulated PPIs holds strong promise for targeting undruggable proteins. However, existing structure-based drug design approaches focus...
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Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning

bioRxiv Jun 29, 2026
Multiple learning signals can shape motor output, including reward and punishment (via value-based reinforcement learning) and sensorimotor error (via motor adaptation). However, it is unclear if action values, learned via reinforcement learning, int...
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Repetitive anatomical patterns for thalamocortical projections of higher-order thalamic nuclei

bioRxiv Jun 28, 2026
Cortico-thalamo-cortical circuits entail extensive trans-thalamic connectivity between cortical areas, yet their structural organization and function remain poorly understood. Here, the thalamocortical projections of several higher-order thalamic nuc...
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A number simplex in the human medial temporal lobe

bioRxiv Jun 28, 2026
Humans handle numbers nimbly, suggesting a richer neural manifold structure than the prevalent mental number line model. In populations of medial temporal lobe (MTL) neurons in humans performing two simple tasks (dot counting and arithmetic), we find...
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Maternal experience alters brain-wide representation of infant cries

bioRxiv Jun 28, 2026
Pup calls signal the presence of a mouse infant in need of care (Bernd Haack et al., 1983; Ehret, 2005). Previous work demonstrated that experience-dependent plasticity within the left primary auditory cortex is oxytocin-facilitated and enhances neur...
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Long-term Learning Induces Plastic Changes in Frontostriatal Circuits

bioRxiv Jun 28, 2026
Neural activity in frontal-striatal circuits underlies reinforcement learning. Traditional theories suggest that reinforcement signals, which drive learning, strengthen connections within the basal ganglia. This strengthening is believed to shift inf...
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Client-server interfaces enable efficient agent-driven variant calling

bioRxiv Jun 28, 2026
Background: Large language model (LLM) agents increasingly automate bioinformatics analyses, but most existing bioinformatics tools were built for standalone use by human experts. An agent driving such a tool must reason about its installation, confi...
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Rett syndrome lifespan extension in mice via AI-guided ADAR editing

bioRxiv Jun 28, 2026
Rett syndrome is a severe neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. A significant subset of severe cases are driven by nonsense mutations that generate premature stop codons, leading to loss of functional MeCP2 prot...
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