Background: Patients with CKD and polypharmacy face high rates of drug-related problems, yet comprehensive medication review remains time-intensive and inconsistently performed. Large language models (LLMs) may augment this process, but existing benc... read more
Objectives: Diabetes affects over 500 million people globally and glycemia is inadequately managed. Metformin is the most frequently prescribed initial treatment for type 2 diabetes globally, yet glycemic response trajectories to metformin in routine... read more
Objectives: The aim of mammographic screening is the early detection of invasive cancers. In the era of artificial intelligence (AI), this tool may improve diagnosis of earlier stages. The purpose of this study was to assess the impact on selected qu... read more
Importance: Leukodystrophies are a heterogeneous group of genetic disorders affecting the white matter of the brain, often presenting with overlapping clinical features but differing in neuroanatomical involvement. There is a critical need for quanti... read more
Computational pathology leverages deep learning to extract clinically relevant information from digitized tumor slides, predicting histopathological subtypes, molecular alterations, and patient outcomes. Recent pipelines increasingly rely on foundati... read more
Background: Stroke is a time-sensitive neurological emergency in which early EMS activation and presentation to definitive care are cornerstones of effective therapy. Large language models (LLMs) are increasingly consulted by the public for medical a... read more
Background: Identifying the geographic origin of epidemic waves early is critical for targeted public health responses. Conventional statistical methods for wave origin estimation rely on fixed algorithms applied to case count time-series data and tr... read more
Objective This study aimed to train and evaluate supervised machine learning algorithms using electronic health record (EHR) data to accurately estimate gestational age at delivery. Materials and Methods We trained random forest, gradient boostin... read more
Background: Accurate extraction of Human Phenotype Ontology (HPO) terms from clinical notes is essential for variant prioritization and genetic diagnosis. Large language models (LLMs) often struggle to balance precision, hallucination avoidance, and ... read more
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