Microbiome-based machine learning classifiers show increasing promise for disease identification across gastrointestinal, metabolic, and immune-mediated conditions. Inflammatory bowel disease (IBD), a chronic immune-mediated disorder associated with ... read more
Bone marrow adiposity changes radically through the lifespan, but this phenomenon is poorly characterised and understood in humans. Large datasets of magnetic resonance imaging (MRI) scans of the head have been collected to study the human brain, but... read more
Alzheimer's disease is a progressive neurodegenerative disorder that poses a growing global public health challenge. Early and accurate diagnosis is critical for effective treatment, clinical trial participation, and disease management. This systemat... read more
Data contamination, from recording errors to extreme outliers, can compromise statistical models by biasing predictions, inflating prediction errors, and, in severe cases, destabilizing performance in high-dimensional settings. Although contamination... read more
Hospital antimicrobial resistance (AMR) emanates from an array of complex interactions between patient turnover, heterogeneous patient--staff contact patterns, antibiotic-driven within-host selection, and imperfect surveillance. We present a hospital... read more
Clinical AI systems have achieved strong predictive performance; however, prediction accuracy is not sufficient for clinical safety. Retrieval-augmented generation (RAG) improves factual accuracy, and general-purpose LLM guardrails constrain surface-... read more
The liver plays a central role in systemic metabolism, yet large-scale genetic studies of quantitative liver imaging phenotypes remain limited. Here, we applied deep learning-based segmentation and radiomics extraction to derive 200 well-defined live... read more
Background: Professionalism and effective communication are foundational determinants of patient safety and quality of care. Unprofessional behaviors frequently serve as active precursors to adverse clinical events. However, proactive organizational ... read more
Background Background breast features are frequently noted in pathology reports alongside invasive breast cancer but rarely factor into prognosis or treatment decisions. Their relationship to tumor characteristics and patient outcomes remains incompl... read more
Background: Machine-learning models based on circulating biomarkers are increasingly used in cardiovascular research; however, model performance alone provides limited insight into how the predictive signal is distributed across features. We aimed to... read more
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