Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterised by uncontrolled immune activation. Reduced high- and low-density lipoprotein cholesterol and hypertriglyceridaemia are reported in HLH, sug... read more
Skin-tone labels are absent from public dermoscopy benchmarks such as the International Skin Imaging Collaboration (ISIC), making it impossible to audit whether clinical AI performs equitably across skin tones. While several recent works estimate ski... read more
Objective: To develop and validate a robust deep-learning model capable of fine-grained phase recognition in total hysterectomy, particularly the complex periuterine dissection phase. Design: Multicentre retrospective observational study. Setting: Ja... read more
Background: Apnoea of prematurity is common and may cause desaturation and/or bradycardia. There is marked variability in infants cardiorespiratory responses to apnoea, despite standardised clinical thresholds. Factors influencing apnoea-related card... read more
Approximately 30-40% of stroke patients retain aphasia at 12 months. Early forecasting may guide rehabilitation and prognostic enrichment of clinical trials, yet machine learning (ML) prediction of language recovery has typically relied on chronic-ph... read more
We present VA-LLM, a 1.62-billion-parameter autoregressive transformer pre-trained from scratch on 1.74 trillion tokens of clinical text spanning 22 years of care for 13.8 million patients in the Veterans Health Administration, with mortality outcome... read more
Querying the RDF Portal knowledge graph maintained by DBCLS, which aggregates approximately 60 life-science databases, requires proficiency in both SPARQL and database-specific RDF schemas, placing this resource beyond the reach of most researchers. ... read more
Cancer is a major global health issue with rising incidence and mortality. Early detection, tumor characterization, and disease surveillance are crucial for timely and effective treatment, ultimately reducing mortality rates. Liquid biopsy (LB) has e... read more
Background: Obesity significantly increases the risk of prognosis and clinical outcomes in pancreatic ductal adenocarcinoma (PDAC). While research on the interactions between obesity and the tumor microenvironment (TME) is mostly confined to a few in... read more
Precise site-specific drug design remains a challenge in structure based drug discovery. Most existing approaches screen for ligands to target binding pockets on a protein surface based on static structures obtained from techniques such as X ray, NMR... read more
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