Objective: To develop and validate a robust deep-learning model capable of fine-grained phase recognition in total hysterectomy, particularly the complex periuterine dissection phase. Design: Multicentre retrospective observational study. Setting: Ja... read more
Background: Apnoea of prematurity is common and may cause desaturation and/or bradycardia. There is marked variability in infants cardiorespiratory responses to apnoea, despite standardised clinical thresholds. Factors influencing apnoea-related card... read more
Approximately 30-40% of stroke patients retain aphasia at 12 months. Early forecasting may guide rehabilitation and prognostic enrichment of clinical trials, yet machine learning (ML) prediction of language recovery has typically relied on chronic-ph... read more
We present VA-LLM, a 1.62-billion-parameter autoregressive transformer pre-trained from scratch on 1.74 trillion tokens of clinical text spanning 22 years of care for 13.8 million patients in the Veterans Health Administration, with mortality outcome... read more
Tissue-level mechanical stimuli are primary drivers of tissue adaptation and can be optimised during conservative treatments to improve treatment outcomes for many highly prevalent musculoskeletal conditions. Current laboratory-based technologies lim... read more
Decision-making circuits are modulated across life stages (e.g. juvenile, adolescent, or adult), as well as on the shorter timescale of reproductive cycles in females, to meet changing environmental and physiological demands. Ovarian hormone signalin... read more
Acoustic monitoring is a scalable approach for assessing bat populations, yet automating the detection and classification of bat echolocation calls remains challenging, particularly in data-scarce regions. Although deep learning (DL) is increasingly ... read more
Nanopore sequencing holds great potential for the direct detection of non-canonical DNA bases from electrical signals, yet current approaches remain limited to a few classical epigenetic marks. Here we present OpenBase, an open and universal framewor... read more
Achieving a trade-off between biological utility and patient privacy remains a key challenge for secure data sharing when applying transcriptomic clinical datasets to artificial intelligence in precision oncology. Here, we introduce the first benchma... read more
Pre-trained genomic language model (gLM) representations have been anticipated to enable enhanced deep learning predictions on several genomics tasks, but current benchmarking has led to questions over what they actually encode. We studied this with ... read more
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