AI Medical Compendium

Integrative multi-omics analysis identifies a core ferroptosis signature and validates resveratrol as a novel inducer in pancreatic cancer.

Naunyn-Schmiedeberg's archives of pharmacology May 16, 2026

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to treatment resistance and an immunosuppressive, fibrotic microenvironment. Ferroptosis, a novel form of regulated cell death, offers a promising therapeutic strategy. Transcriptomic... read more

Hidden Preoperative Lower-Extremity Venous Thrombosis in Pelvic Organ Prolapse Surgery: Prevalence and Development of a Clinical Prediction Model.

International urogynecology journal May 16, 2026

INTRODUCTION AND HYPOTHESIS: Preoperative lower-extremity venous thrombosis (LEVT) is frequently overlooked in women undergoing pelvic organ prolapse (POP) surgery, despite its potential impact on perioperative outcomes. Conventional risk tools, incl... read more

Aging beyond diagnosis: the MRI brain age gap across disorders.

GeroScience May 16, 2026

The brain age gap (BAG), the difference between magnetic resonance imaging-predicted brain age and chronological age, is a proposed marker of neurobiological aging, yet its transdiagnostic significance remains uncertain. This meta-analysis evaluated ... read more

From forensic medical databases to court-defensible artificial intelligence: the next translational step is standards, not scale.

Forensic science, medicine, and pathology May 16, 2026

Comparative study on the efficacy of large language models (LLMs) in health management for patients with urological and andrological diseases: a multidimensional quality evaluation and applicability analysis.

World journal of urology May 16, 2026

PURPOSE: This study aims to evaluate the efficacy of large language models (LLMs) in health management for urological and andrological conditions by comparing two Chinese LLMs: DeepSeek and Kimi. METHODS: The responses of DeepSeek and Kimi to 30 ques... read more

Coronary stenosis assessment: AI-based CT quantification, visual analysis of invasive angiography, and quantitative coronary angiography.

Insights into imaging May 16, 2026

OBJECTIVE: To evaluate the diagnostic performance for coronary stenosis of artificial intelligence (AI)-based CT quantification, manual CT quantification, and visual invasive coronary angiography (ICA) assessment against quantitative coronary angiogr... read more

An interpretable PET/CT-based radiomic-clinical model for predicting bone marrow involvement in follicular lymphoma: comparison of pelvic and spine-pelvis VOI frameworks.

European journal of nuclear medicine and molecular imaging May 16, 2026

PURPOSE: To investigate the feasibility of non-invasively identifying bone marrow involvement (BMI) in follicular lymphoma (FL) using baseline 18F-FDG PET/CT combined with multidimensional feature fusion, and to compare the impact of different bone m... read more

Transcriptomic Analysis and Multiple Machine Learning Approaches Identify ZDHHC20 and Its Highly Correlated Gene AK5 as Biomarkers in Multiple System Atrophy.

Journal of molecular neuroscience : MN May 16, 2026

Multiple system atrophy (MSA) is a fatal neurodegenerative disorder lacking effective diagnostic tools. While protein palmitoylation is crucial for neuronal function, its specific role in MSA pathogenesis remains unexplored. We integrated bulk and si... read more

Breaking glycolysis: allosteric hotspots for multi-target drug repurposing.

Journal of computer-aided molecular design May 16, 2026

Glycolysis is essential for cellular energy production, making its enzymes attractive antimicrobial targets. Traditional strategies targeting conserved catalytic sites risk host toxicity due to limited species specificity. Allosteric sites-spatially ... read more

Humanized-Intelligent-Green Chemistry (hiGC) Paradigm: Advancing Beyond Traditional Green Chemistry Illustrated by Ionic Liquids and Deep Eutectic Solvents.

Chemistry (Weinheim an der Bergstrasse, Germany) May 16, 2026

Ionic liquids (ILs) and deep eutectic solvents (DESs) are two types of innovative green solvents that significantly enhance the development of green chemistry. The 12 principles proposed by Anastas et al. in 1998 have guided the advancement of green ... read more

Artificial Intelligence Medical Compendium