Alzheimer's disease (AD) is a major cause of dementia, and this paper explores the unclear roles of mitochondrial dysfunction and programmed cell death in AD. Differentially expressed genes (DEGs) were identified using AD datasets GSE63061 and GSE630... read more
We aimed to build a fuzzy logic preanaesthetic risk score tailored to cataract surgery. By fusing systemic comorbidities with key patient attributes in an adaptive rule base, our goal was to generate patient-specific risk estimates that move beyond t... read more
Parkinson disease (PD) is a rapidly growing neurodegenerative disorder that presents a significant public health challenge in aging societies, particularly in China. Although genetic, clinical, and environmental risk factors have been well-establishe... read more
Simultaneous prediction of multiple air pollutants is essential for quantifying human co-exposure and evaluating the health impacts of pollutant mixtures. However, spatial and temporal gaps in geostationary satellite observations, chemical transport ... read more
Journal of chemical information and modeling
Mar 20, 2026
Uncharacterized functions of enzymes represent an untapped opportunity to develop therapeutics, unlock the sustainable synthesis of materials, and understand the evolution of life-sustaining metabolic networks. Uncharacterized enzymes and reactions, ... read more
Journal of chemical information and modeling
Mar 20, 2026
Precise determination of protein functions is essential for elucidating cellular processes and pathological mechanisms, thereby facilitating targeted drug design. Although wet-lab experimental methods remain the gold standard to determine protein fun... read more
Incorporating prespecified Google Trends indicators into leakage-controlled stacked-ensemble models improved a 2025 holdout prediction of subjective well-being by using 2022-2025 data from Japan's 47 prefectures, reducing the mean squared error from ... read more
BACKGROUND: Artificial intelligence (AI) has shown promise for automating spinal alignment assessment in adolescent idiopathic scoliosis (AIS). However, AI models typically exhibit reduced accuracy and robustness when deployed across multiple medical... read more
Rapid and accurate screening of protein-ligand binding affinities using machine learning (ML) remains a challenging yet critical task in drug discovery. In this work, two closely related challenges are addressed: the inherent sensitivity of the bindi... read more
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