Proteolysis-targeting chimeras (PROTACs) are transforming targeted therapeutics by enabling the selective and catalytic degradation of disease-associated proteins, offering new treatment avenues in oncology, neurodegeneration, immunology, and infecti... read more
Biochemical and biophysical research communications
Dec 31, 2025
OBJECTIVE: Airborne environmental contaminants are established carcinogens. This investigation elucidates the mechanistic contributions to pulmonary adenocarcinoma (LUAD) pathogenesis. METHODS: Transcriptomic profiling through differential expression... read more
Artificial Intelligence (AI) holds significant promise for healthcare but often struggles to transition from development to clinical integration. This paper argues that Learning Health Systems (LHS)-socio-technical ecosystems designed for continuous ... read more
2D-3D cross-dimensional registration serves as a critical technology in spinal surgery navigation, with profound implications for enhancing surgical precision, reducing radiation exposure and mitigating surgical risks. Its core objective is to achiev... read more
Given the increasing data requirements of deep learning models and the scarcity of medical imaging data, new data augmentation techniques are receiving particular attention. This paper explores the subfield of tumour synthesis within medical image ge... read more
Environmental pollution (Barking, Essex : 1987)
Dec 31, 2025
Air pollution, which poses a global threat to human and ecosystem health, has been extensively monitored by governments and researchers worldwide. However, the effects of air pollution on river ecosystems, particularly riverine microorganisms, have r... read more
Reproductive performance affects the profitability of a dairy herd. The ability to understand the reproductive capabilities of individual cows and the use of targeted reproductive management could optimize reproductive performance of dairy herds. To ... read more
To investigate the role of lipid metabolism abnormalities in the progression of osteoporosis (OP), clarify the impact of the key regulator angiopoietin-like protein 4 (ANGPTL4) on the adipogenic-osteogenic differentiation balance of bone marrow mesen... read more
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Dec 31, 2025
The detection of weak radioactive sources in fluctuating background environments is a critical task for nuclear security, environmental monitoring, and emergency response. Compact gamma-ray detectors, such as small-volume CdZnTe (CZT) crystals, are w... read more
Setiu Wetlands on the east coast of Peninsular Malaysia have been facing a significant impact of the changed hydrodynamics and sedimentation due to the shifted river mouth. In particular, sand accumulation over the mangrove areas is threatening veget... read more
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