Managing a patient with uveitis in the era of artificial intelligence: Current approaches, emerging trends, and future perspectives.

Journal: Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
PMID:

Abstract

The integration of artificial intelligence (AI) with healthcare has opened new avenues for diagnosing, treating, and managing medical conditions with remarkable precision. Uveitis, a diverse group of rare eye conditions characterized by inflammation of the uveal tract, exemplifies the complexities in ophthalmology due to its varied causes, clinical presentations, and responses to treatments. Uveitis, if not managed promptly and effectively, can lead to significant visual impairment. However, its management requires specialized knowledge, which is often lacking, particularly in regions with limited access to health services. AI's capabilities in pattern recognition, data analysis, and predictive modelling offer significant potential to revolutionize uveitis management. AI can classify disease etiologies, analyze multimodal imaging data, predict outcomes, and identify new therapeutic targets. However, transforming these AI models into clinical applications and meeting patient expectations involves overcoming challenges like acquiring extensive, annotated datasets, ensuring algorithmic transparency, and validating these models in real-world settings. This review delves into the complexities of uveitis and the current AI landscape, discussing the development, opportunities, and challenges of AI from theoretical models to bedside application. It also examines the epidemiology of uveitis, the global shortage of uveitis specialists, and the disease's socioeconomic impacts, underlining the critical need for AI-driven approaches. Furthermore, it explores the integration of AI in diagnostic imaging and future directions in ophthalmology, aiming to highlight emerging trends that could transform management of a patient with uveitis and suggesting collaborative efforts to enhance AI applications in clinical practice.

Authors

  • William Rojas-Carabali
    National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
  • Carlos Cifuentes-González
    Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
  • Laura Gutierrez-Sinisterra
    Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore.
  • Lim Yuan Heng
    Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address: yuanheng03@gmail.com.
  • Edmund Tsui
    Stein Eye Institute, David Geffen of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: etsui@mednet.ucla.edu.
  • Sapna Gangaputra
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: sapna.gangaputra@vumc.org.
  • Srinivas Sadda
    Doheny Eye Institute, Los Angeles, CA, 90033, USA.
  • Quan Dong Nguyen
    Byers Eye Institute, Stanford University, Palo Alto, California, USA.
  • John H Kempen
    Department of Ophthalmology, Massachusetts Eye and Ear/Harvard Medical School, and Schepens Eye Research Institute, Boston, Massachusetts, USA.
  • Carlos E Pavesio
    Moorfields Eye Hospital, NHS Foundation Trust, London, UK. Electronic address: c.pavesio@nhs.net.
  • Vishali Gupta
    Post Graduate Institute of Medical Education and Research (PGIMER), Advance Eye Centre, Chandigarh, India.
  • Rajiv Raman
    Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
  • Chunyan Miao
    1Joint NTU-UBC Research Centre of Excellence in Active Living for the Elderly (LILY), Nanyang Technological University, Singapore, 639798 Singapore.
  • Bernett Lee
    National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
  • Alejandra de-la-Torre
    National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
  • Rupesh Agrawal
    MyungSung Christian Medical Center (MCM) Eye Unit, MCM Comprehensive Specialized Hospital, and MyungSung Medical School, Addis Ababa, Ethiopia.