BACKGROUND: Anopheles mosquitoes pose notable public health concerns as competent vectors of malaria and other diseases. Although malaria is no longer endemic in the United States, recent locally acquired cases in states including Maryland highlight ...
The BBB remains a major obstacle to effective treatment of CNS disorders by limiting the entry of most therapeutics into the brain. The hCMEC/D3 is widely used as anin vitromodel to study BBB structure, permeability, and drug transport. In parallel, ...
The concept of logical neural networks, proposed by McCulloch and Pitts, along with Hebb's postulate of learning-specifically, spike-timing-dependent plasticity (STDP), has had a substantial influence on the development of brain-inspired computing re...
BACKGROUND: Staphylococcus aureus (S. aureus) pneumonia constitutes a lethal respiratory infection with persistently high clinical mortality. Although programmed cell death (PCD) pathways are implicated in diverse disease processes, their mechanistic...
BACKGROUND: Abdominal aortic aneurysm (AAA) refers to a lasting enlargement of the abdominal aorta. Senescence, a major risk factor of AAA, demonstrate positive connection with both the formation and rupture of aneurysms. Therefore, investigating the...
A heart-convolutional neural network (heart-CNN) was developed and tested for the automatic detection of left atrial enlargement (LAE) from feline thoracic radiographs. A retrospective and multicenter study was performed. Right lateral and dorso-vent...
Tauopathies are characterised by a progressive accumulation of hyperphosphorylated tau. However, early and intermediate stages remain challenging to quantify due to subtle and heterogeneous morphological characteristics. This study evaluates a deep l...
Intracellular action potential (AP) recording that allows long-term monitoring is challenging because permanent membrane penetration is impossible due to cell death or resealing of perforated cell membrane. Herein, an "inherited noninvasive intracell...
Mammalian genome : official journal of the International Mammalian Genome Society
Jan 16, 2026
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are major public health challenges lacking effective therapies. To identify potential drug targets, we integrated large-scale genome-wide association ...
A recurrent neural network fitted to large electrophysiological datasets may help us understand the chain of cortical information transmission. In particular, successful network reconstruction methods should enable a model to predict the response to ...
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