Integrated deep learning model for automatic detection and classification of stenosis in coronary angiography.

Journal: Computational biology and chemistry
Published Date:

Abstract

Coronary artery disease poses a significant threat to human health. In clinical settings, coronary angiography remains the gold standard for diagnosing coronary heart disease. A crucial aspect of this diagnosis involves detecting arterial narrowings. Categorizing these narrowings can provide insight into whether patients should receive vascular revascularization treatment. The majority of current deep learning methods for analyzing coronary angiography are mostly confined to the theoretical research domain, with limited studies offering direct practical support to clinical practitioners. This paper proposes an integrated deep-learning model for the localization and classification of narrowings in coronary angiography images. The experimentation employed 1606 coronary angiography images obtained from 132 patients, resulting in an accuracy of 88.9 %, a recall rate of 85.4 %, an F1 score of 0.871, and a MAP value of 0.875 for vascular stenosis detection. Furthermore, we developed the "Hemadostenosis" web platform (http://bioinfor.imu.edu.cn/hemadostenosis) using Django, a highly mature HTTP framework. Users are able to submit coronary angiography image data for assessment via a visual interface. Subsequently, the system sends the images to a trained convolutional neural network model to localize and categorize the narrowings. Finally, the visualized outcomes are displayed to users and are downloadable. Our proposed approach pioneers the recognition and categorization of arterial narrowings in vascular angiography, offering practical support to clinical practitioners in their learning and diagnostic processes.

Authors

  • Tao Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiaojun Su
    College of Computer Science, Inner Mongolia University, Hohhot 010021, China.
  • Yuchao Liang
    The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
  • Xu Luo
    Southwest Hospital, Third Military Medical University, Chongqing, 400038 China.
  • Xiao Hu
    Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, United States.
  • Ting Xia
    School of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China; Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, Guangdong Province, China.
  • Xuebin Ma
    College of Computer Science, Inner Mongolia University, Hohhot 010021, China.
  • Yongchun Zuo
    The State key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
  • Huilin Xia
    Medical Engineering development, Inner Mongolia People's Hospital, Hohhot 010010, China. Electronic address: nmyyxhl@163.com.
  • Lei Yang
    George Mason University.