Unbiased identification of risk factors for invasive Escherichia coli disease using machine learning.

Journal: BMC infectious diseases
PMID:

Abstract

BACKGROUND: Invasive Escherichia coli disease (IED), also known as invasive extraintestinal pathogenic E. coli disease, is a leading cause of sepsis and bacteremia in older adults that can result in hospitalization and sometimes death and is frequently associated with antimicrobial resistance. Moreover, certain patient characteristics may increase the risk of developing IED. This study aimed to validate a machine learning approach for the unbiased identification of potential risk factors that correlate with an increased risk for IED.

Authors

  • Erik Clarke
    Janssen Research and Development Data Sciences, Spring House, PA, USA.
  • Christel Chehoud
    Janssen Pharmaceuticals, Inc, Raritan, New Jersey.
  • Najat Khan
    Janssen Research and Development Data Sciences, Spring House, PA, USA.
  • Bart Spiessens
    Janssen Research and Development, Beerse, Belgium.
  • Jan Poolman
    Janssen Vaccines and Prevention, Leiden, The Netherlands.
  • Jeroen Geurtsen
    Janssen Vaccines and Prevention, Leiden, The Netherlands. jgeurtse@its.jnj.com.