Foundation models in ophthalmology.

Journal: The British journal of ophthalmology
Published Date:

Abstract

Foundation models represent a paradigm shift in artificial intelligence (AI), evolving from narrow models designed for specific tasks to versatile, generalisable models adaptable to a myriad of diverse applications. Ophthalmology as a specialty has the potential to act as an exemplar for other medical specialties, offering a blueprint for integrating foundation models broadly into clinical practice. This review hopes to serve as a roadmap for eyecare professionals seeking to better understand foundation models, while equipping readers with the tools to explore the use of foundation models in their own research and practice. We begin by outlining the key concepts and technological advances which have enabled the development of these models, providing an overview of novel training approaches and modern AI architectures. Next, we summarise existing literature on the topic of foundation models in ophthalmology, encompassing progress in vision foundation models, large language models and large multimodal models. Finally, we outline major challenges relating to privacy, bias and clinical validation, and propose key steps forward to maximise the benefit of this powerful technology.

Authors

  • Mark A Chia
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
  • Fares Antaki
    Department of Ophthalmology, University of Montreal, Montreal, QC H3T 1J4, Canada.
  • Yukun Zhou
    Centre for Medical Image Computing, University College London, London, UK.
  • Angus W Turner
    Lions Outback Vision, Lions Eye Institute, Nedlands, Western Australia, Australia; University of Western Australia, Perth, Western Australia, Australia.
  • Aaron Y Lee
    Department of Ophthalmology, University of Washington, Seattle, Washington.
  • Pearse A Keane
    National Institute for Health Research Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.