Improved prediction of post-translational modification crosstalk within proteins using DeepPCT.
Journal:
Bioinformatics (Oxford, England)
PMID:
39570595
Abstract
MOTIVATION: Post-translational modification (PTM) crosstalk events play critical roles in biological processes. Several machine learning methods have been developed to identify PTM crosstalk within proteins, but the accuracy is still far from satisfactory. Recent breakthroughs in deep learning and protein structure prediction could provide a potential solution to this issue.