Experts fail to reliably detect AI-generated histological data.

Journal: Scientific reports
Published Date:

Abstract

AI-based methods to generate images have seen unprecedented advances in recent years challenging both image forensic and human perceptual capabilities. Accordingly, these methods are expected to play an increasingly important role in the fraudulent fabrication of data. This includes images with complicated intrinsic structures such as histological tissue samples, which are harder to forge manually. Here, we use stable diffusion, one of the most recent generative algorithms, to create such a set of artificial histological samples. In a large study with over 800 participants, we study the ability of human subjects to discriminate between these artificial and genuine histological images. Although they perform better than naive participants, we find that even experts fail to reliably identify fabricated data. While participant performance depends on the amount of training data used, even low quantities are sufficient to create convincing images, necessitating methods and policies to detect fabricated data in scientific publications.

Authors

  • Jan Hartung
    Institute for Physiology, Faculty of Medicine, University of Freiburg, 79108, Freiburg, Germany. jan.hartung@physiologie.uni-freiburg.de.
  • Stefanie Reuter
    ThIMEDOP, Jena University Hospital, Nonnenplan 4, 07745, Jena, Germany.
  • Vera Anna Kulow
    Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Translationale Physiologie (CCM), Charitéplatz 1, 10117, Berlin, Germany.
  • Michael Fähling
    Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Translationale Physiologie (CCM), Charitéplatz 1, 10117, Berlin, Germany.
  • Cord Spreckelsen
    Department of Medical Informatics, Medical Faculty, RWTH Aachen University.
  • Ralf Mrowka
    Experimentelle Nephrologie, KIMIII, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Jena, Germany.