A machine-learning-based algorithm for bone marrow cell differential counting.

Journal: International journal of medical informatics
PMID: 39549389

Abstract

BACKGROUND: Differential counting (DC) of different cell types in bone marrow (BM) aspiration smears is crucial for diagnosing hematological diseases. However, a clinically applicable method for automatic DC has yet to be developed.

Authors

  • Ta-Chuan Yu
    Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, No. 579, Sec. 2, Yunlin Rd., Douliu City, Yunlin County 640203, Taiwan.
  • Cheng-Kun Yang
  • Wei-Han Hsu
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Cheng-An Hsu
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Hsiao-Chun Wang
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Hsin-Jung Hsiao
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Hsiao-Ling Chao
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Han-Peng Hsieh
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Jia-Rong Wu
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Yen-Chun Tsai
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Yi-Mei Chiang
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Poshing Lee
    BioReference Labs, 481 Edward H. Ross Drive Elmwood Park, NJ 07407, United States.
  • Che-Pin Lin
    Cathy General Hospital, No. 280, Section 4, Ren'ai Rd, Da'an District, Taipei City 106, Taiwan.
  • Ling-Ping Chen
    Cathy General Hospital, No. 280, Section 4, Ren'ai Rd, Da'an District, Taipei City 106, Taiwan.
  • Yung-Chuan Sung
    Cathy General Hospital, No. 280, Section 4, Ren'ai Rd, Da'an District, Taipei City 106, Taiwan.
  • Ya-Yun Yang
    Cathy General Hospital, No. 280, Section 4, Ren'ai Rd, Da'an District, Taipei City 106, Taiwan.
  • Chin-Ling Yu
    Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, No. 579, Sec. 2, Yunlin Rd., Douliu City, Yunlin County 640203, Taiwan.
  • Chih-Kang Lin
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Chia-Pin Kang
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Che-Wei Chang
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
  • Hsiu-Lin Chang
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Jung-Hsuan Chu
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Kai-Ling Cathy Kao
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Li Lin
    Department of Cardiology, Lishui Central Hospital and the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China.
  • Min-Sheng Wu
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Pei-Chen Lin
    Graduate Institute of Biomedical Informatics, College of Medicine Science and Technology, Taipei Medical University, Taipei, Taiwan; Emergency Department, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
  • Po-Hsu Yang
    aetherAI, Co., Ltd., 9F, No. 3-2, Park Street, Nangang District, Taipei 115, Taiwan.
  • Qun-Yi Zhang
    aetherAI, Co, Ltd, Taipei, Taiwan.
  • Ming-Kai Chuang
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Sheng-Chieh Chou
    Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Sheng-Chuan Huang
    Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, 100, Taiwan; Department of Hematology and Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Department of Clinical Pathology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Chieh-Lung Cheng
    Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Chi-Yuan Yao
    Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Feng-Ming Tien
    Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S Rd, Zhongzheng District, Taipei City 100, Taiwan.
  • Chao-Yuan Yeh
  • Wen-Chien Chou
    Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Keywords

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