Prediction of antibody-antigen interaction based on backbone aware with invariant point attention.
Journal:
BMC bioinformatics
PMID:
39506679
Abstract
BACKGROUND: Antibodies play a crucial role in disease treatment, leveraging their ability to selectively interact with the specific antigen. However, screening antibody gene sequences for target antigens via biological experiments is extremely time-consuming and labor-intensive. Several computational methods have been developed to predict antibody-antigen interaction while suffering from the lack of characterizing the underlying structure of the antibody.